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… DAN: You’re listening to the US Department of Energy Joint Genome Institute’s … natural products and fungi are induced by growing beside a bacterium and I’m sure the opposite way around, because … clusters that, you know, maybe are not expressed in the producing fungus. Yyou put them in a heterologous system, …

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… is Professor Cassandra Quave from Emory University, with joint appointments in the School of Medicine and College of … QUAVE: Yeah, so I mean my path towards natural products and medical ethnobotany really began with early childhood … on several antibiotic resistant microbes including a bacterium called methicillin-resistant Staphylococcus aureus …

… DAN UDWARY: You’re listening to the Department of Energy Joint Genome Institute’s … often live in symbiosis with plants and might actually be producing molecules that are helpful to the plants. And so, … really done a somewhat exhaustive chemical analysis of a bacterium that they’re interested in, usually some sort of …

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… DAN: You’re listening to the US. .Department of Energy Joint Genome … so go check it out – but basically tied how the antibiotic producing bacteria on the ants related geography and … strange to me, but I’m new, so… DAN: Well, you know, every bacterium that’s killing another bacterium is an ecological …

… growth, provide critical advantages to the organisms producing them, and are often involved in defense, nutrient acquisition and communication. … algae and plants. These compounds are key to organisms' interactions with their environments and with each other, …

… of Natural Prodcast. A little bit of a bonus episode, since I’m off schedule, but this is an important one that … metals, so these concentrations of arsenic and lead and mercury are pretty high as well. And these organisms have no … WINTER: You’re going to single-handedly cause like massive brownouts in California when you’re doing the computational …

… DAN: You’re listening to the US Department of Energy Joint Genome Institute’s … inspired people to make use of this molecule for biomedical application. So the Yeah, ALISON: But how? I mean, … And so that’s a big collection of natural product-producing organisms that Pfizer, you know, mined for years …

… Hey, everyone. I’ve got a great episode for you here today. We got the opportunity to talk to one of the real … of natural products, Professor Bill Fenical from Scripps Institution of Oceanography in San Diego. Bill is a pioneer … half or more require salt. So how do you define a marine bacterium? I think you define it by perhaps having a salt …

… DAN: You’re listening to the US Department of Energy Joint Genome Institute’s … Sounds like. DAN: Literally, yeah. I mean, you might be producing things at different stages of growth or different … going to set in. The more you use an antibiotic, the more a bacterium is exposed to it, the greater the chance that that …

… DAN UDWARY: You’re listening to the Department of Energy Joint Genome Institute’s … Europe. So if there are any kind of dated references to the news, that’s why. But it was a really fun conversation. And … sure. NADINE ZIEMERT: Yeah, Dan… it’s a marine actinomycete bacterium. So they look kind of like fungi but also make …