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The Fungal & Algal Program explores the vast diversity of fungi and algae to unlock their potential for bioenergy, environmental sustainability, and bioproducts. By sequencing and analyzing the … on large-scale sequencing efforts that survey the vast phylogenetic and ecological diversity of fungi and algae, …

… the exploration of secondary metabolites across bacteria, fungi, algae and plants. These molecules, which are not … communication. Studying how these compounds are biosynthesized and their roles in the environment, can unlock new … conditions, with only a small portion of the biosynthetic gene clusters (BGCs) being expressed. The program works to …

Master’s student at the University of Groningen and then I wrote my own grant proposal in the hope that it would get … Marnix Medema: Yeah, exactly. There is no black and white in clustering in general in computer science. Dan … metabolomics, and natural products in plants, fungi, and microorganisms. If you want to collaborate, let …

… itself medicine, but the coding within the DNA codes for proteins that do the chemistry that put molecules together … in the earlier primers. In bacteria, at least, and in most fungi, biosynthetic gene clusters, which are the genes that … cluster makes a product and how a product should be synthesized based on its structure, that we should be able to tie …

… metabolomics fuels the discovery  of novel metabolites, genes, and proteins. It also enables exploration of energy and nutrient … biological and environmental samples — including microbes, fungi, plants and soils. Through a combination of …

… be the amino acid that is relevant for the synthesis of proteins, and will more often end up in the active site of an … are microbes that will actually redefine how you synthesize nucleotides. Stuff that are at the core of what we call … metabolomics, and natural products in plants, fungi, and microorganisms. If you want to collaborate, let …

… bacterial sacred metabolite, and ergot alkaloids come from fungi, and Taxol from plants. Plants, fungi, bacteria, … They might have enough nutrients, but they might want to protect those nutrients with antibiotics. They might need to … like a bunch of colonies on a petri dish. It’s a black and white photo. It almost looks like the moon, because you have …

… are the RiPPs, which stands for “Ribosomally synthesized and Post-translationally modified Peptides.” You’ll … on this: Most of the machinery in any living organism are proteins, which are made up of chains of amino acids. … marine organisms. Except during the time that we worked in fungi. But what do you see as the overall theme of your …

… with Christian, I started getting a little bit more into fungi and learning the differences of all the genetic … types of particulate like 2.5, 10 PPMs and just the size of the particle and how far they can actually travel. … are not publicly available because sometimes we want to protect the clusters we’re working on and not get scooped. …

Diversity . And there’s something called the Nagoya Protocol on access and benefit sharing. And for a very long … nothing for. We’re also working on organisms, pathogenic fungi like Candida aureus in the lab and we work on … what season they should be collected, what girth or size of the branches should be, there are all these other …

… just deposit and take off. And so they must be chemically protected in some way and lo and behold it’s this bacteria. … working on that aspect and it’s quite active against some fungi. But we’re also really interested in distribution. So … there’s no reason for that diversity of thought to be all white males for sure. And I think natural products does a …

… to regulate Earth's carbon balance, to exploring the genetic basis of how plants have naturally adapted to varied … including deep learning algorithms for gene annotation and protein folding models, to improve the accuracy of functional … … Phytozome is the JGI's Plant Comparative Genomics portal. Families of related genes representing the modern …