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Researchers looked across many organisms to see that aminotransferase enzymes have evolved mix-and-match characteristics — … this gap, by tracing the evolution of a specific enzyme family called aminotransferases (ATs). These enzymes play a …

… … DAN UDWARY: You’re listening to the Department of Energy … for you. A lot of this is based on a really great paper that came out in 2020 where this is all explained in detail, … will be very flexible. They will allow promiscuity and the enzymes are driving the production of these compounds, …

… … DAN UDWARY: Hey everyone. Welcome back to Natural Prodcast. … as exploring and exploiting biocatalysts – that is, using enzymes to do chemical reactions. Obviously, in my work, in … in a route towards many different compounds in the same family. And so that you want it to have some promiscuity in …

… … DAN: You’re listening to the US Department of Energy Joint … pathways. Not every organism, at least, has something that’s maybe obvious or notable. We are still in – not an … I think is also really interesting. Because glycosides are shaped so differently from polyketides. At least I mean, I …

With collaborative user projects, the JGI’s Plant Program delves into the natural world’s potential to … core, the program investigates photosynthesis — the process that transforms solar energy into chemical energy — and its … the vulnerabilities of monocultures and the benefits of nitrogen-fixing nodules in legumes, which can reduce …

… … DAN: You’re listening to the US Department of Energy Joint … darn cool to have that legacy and that running in your family. Dan: So tell me about that. What sparked it? I mean, … might make this molecule and predicting what kind of enzymes might be involved, and then being able to make those …

… … Dan Udwary: You’re listening to the Department of Energy … some of these enormous genes that encode these very large enzymes. And I was like, OK, wow, these are really cool. And … nicer than MIBiGC or MIBIC. Dan Udwary: Yeah. And the big family continues. So next I think was BiG-SCAPE and now …

DAN UDWARY: You’re listening to the Department of Energy … there was a biosynthetic gene cluster there. But that’s one family of biosynthetic genes. And so, I think antiSMASH– oh, … ago. Non-ribosomal peptides, remember, are big, complicated enzyme systems that really just exist to pull an amino acid …

… … DAN: Hello, everyone, and Welcome back for Episode 14 of … Gluconibacter .  And that got me back a little bit to redox enzymes and looking at gene regulation. And then from there, … of about 75 people. So our biggest project was the spinosyn family of insecticides that Dow had already commercialized …

… … DAN UDWARY: Hey everyone and welcome back to a new session of … microbiomes, and using engineered biosynthetic pathways and enzyme systems to do synthetic analoging of some really … On target identification and cancer biology: “Apoptolidin family glycomacrolides target leukemia through inhibition of …

… … DAN UDWARY: Hey, everyone! Welcome to the “Self Promotion … cool. The vanadium haloperoxidases are some really cool enzymes, and it was fun to see that project take shape. … JACLYN WINTER: So I actually– well, I mean, not having family in science, it was hard to see what are the different …