Search

… to unlock their potential for bioenergy, environmental sustainability, and bioproducts. By sequencing and analyzing the … on large-scale sequencing efforts that survey the vast phylogenetic and ecological diversity of fungi and algae, … The  1000 Fungal Genomes Project is a five-year project to sequence 1000 fungal genomes from across the Fungal Tree of …

And at the time, it was really exciting when people would sequence [DNA]. The genome was– well, that hadn’t really … It was unpublished at that point. But people would push out gene clusters maybe once a month at most. Maybe twice a … polyketide synthase and then P3. We still don’t know why 20 years later. JACKIE WINTER: It’s pretty amazing, …

Program works to uncover the roles of small molecules in biological systems, linking them with genomic data to … metabolomics fuels the discovery  of novel metabolites, genes, and proteins. It also enables exploration of energy … health, and bioenergy development. … EcoFABs:  For studying microbe-host (or plant-microbiome) interactions …

… least, talk to us, first about my definitions of things and why I am wrong, and also talk about some of the great … the active site of an enzyme. So there is no promiscuity, generally speaking, in primary metabolism. Nevertheless, … to approach it is more related to what JGI does, which is sequence genomes. And we just published last year in the …

… learned a lot so much history from this conversation about why the ocean was basically unexplored until the 70s, and … survival. Those molecules, over evolutionary time, become targeted to certain biological systems in the target … forward to seeing the data when it finally gets off the sequencers. The pandemic has obviously slowed JGI down a …

… there are any kind of dated references to the news, that’s why. But it was a really fun conversation. And I think … of it. So it wasn’t only chemistry or only biochemistry or genetics. It was also ecology. It was also evolution. It was … it would work, but we actually found fosmids. And we sequenced the whole fosmid at the time with Sanger …

… in defense, nutrient acquisition and communication. Studying how these compounds are biosynthesized and their … conditions, with only a small portion of the biosynthetic gene clusters (BGCs) being expressed. The program works to … computational analyses of BGC size and complexity, BGC sequence composition, metabolic similarity & compatibility, …

When submitting sequences to the JGI DNA Synthesis program, please … written by M. Wayne Davis or commercial options include SnapGene . … How To Use ApE To save your ApE file as a Genbank …

How’s it going, Eric?  ERIC:  Good. It’s an honor to be targeted by you, Dan. DAN: I’m not quite sure where to start … you maybe explain what’s going on with their biology and why they’re so important to natural products? ERIC:  Sure. … turns a peptide, for example, from a disordered sequence into an antibiotic that kills bacteria through a …

… about the basics of genome mining, which is using DNA sequence to identify and interpret biosynthetic, secondary … and BiG-SLiCE, and now the BiG-FAM database of biosynthetic gene cluster families. And he tells us about forthcoming … biological perspective, like what was this bacterium, and why did your group want to study it? Marnix Medema: You mean …

The JGI has diverse capabilities in: DNA and RNA sequencing, Sample and library preparation, … sequencing products below. In addition, JGI will submit raw sequence data to  SRA at NCBI once the standard analysis is … percentile*) DNA Synthesis Constructs <5kb in size Single gene or multiple small genes assembled to less than 5kb in …

… more than 50,000 genomes that we derived from meta-genome sequences. As always, you’ll find transcripts and show notes … ALISON TAKEMURA: I know that it’s looking in the genome for genetic elements of interest, you know, something like … for us– what organisms people use for genome mining, why it’s called genome mining, how the biosynthetic gene …