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When submitting sequences to the JGI DNA Synthesis program, please include the following items: … Sequence files for all constructs should be emailed to  … several easy-to-use open source tools for converting DNA sequence files into well-formed GenBank files. ApE is an …

… more than 50,000 genomes that we derived from meta-genome sequences. As always, you’ll find transcripts and show notes … find, things that are of interest. And usually, in terms of bacteria and secondary metabolism, those things that we want … for us– what organisms people use for genome mining, why it’s called genome mining, how the biosynthetic gene …

… to explore the vast and diverse world of microbes. Studying bacteria and archaea, including those associated with … resequencing, RNA sequencing and epigenomics. Expansion of sequence space:  The JGI generates reference genomes from … of microbial communities based on their metagenome sequence, in the context of reference isolate genomes …

… chemical compounds that you find in plants, fungi and bacteria, basically all living things. When your crazy Aunt is posting … stories about natural products, so you can get a feel for why I think they’re so important, and we’ll start to explain …

… work like ActDES, which is a curated database of actinobacteria for evolutionary studies, and hopefully we can … least, talk to us, first about my definitions of things and why I am wrong, and also talk about some of the great … to approach it is more related to what JGI does, which is sequence genomes. And we just published last year in the …

… learned a lot so much history from this conversation about why the ocean was basically unexplored until the 70s, and … into the secondary metabolism of some more novel marine bacteria. You know, I first met Bill as a postdoc working … forward to seeing the data when it finally gets off the sequencers. The pandemic has obviously slowed JGI down a …

… there are any kind of dated references to the news, that’s why. But it was a really fun conversation. And I think … they spread, why do they spread in a certain way from one bacteria to another, how do they change then, and why are … it would work, but we actually found fosmids. And we sequenced the whole fosmid at the time with Sanger …

And a lot of us moved on to work in simpler systems, like bacteria, where we figure we can make more progress faster, … you maybe explain what’s going on with their biology and why they’re so important to natural products? ERIC:  Sure. … turns a peptide, for example, from a disordered sequence into an antibiotic that kills bacteria through a …

… the paradigm of how to discover natural products. So, why I’m very excited to be working with Dan, you, with the … develop enabling technologies. ie how to translate the ATGC sequence into discrete small molecules. So, Dan, I’m very … origin is around 30,000 from fungal, and a 40,000 from bacteria. Okay? And among the 40,000 from bacteria, there’s …

… cell types and associated organisms, including fungal and bacterial symbionts, detrimental microbial pathogens, and … This is a dynamic and complex ecosystem that includes bacteria, fungi, viruses. Resident viruses can be found in a myriad of bacterial strains, whereby they can modulate host …