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… be hearing about microbiology and natural products from the Great Salt Lake, and you’re going to learn, like me, what a … is like, what’s your origin story in natural products? Why are you doing this? JACLYN WINTER: I’ll kind of go back … have an E. coli strain that we’ve been working on that we sequenced the genome. And it has 17 resistant genes on a …

When submitting sequences to the JGI DNA Synthesis program, please include the following items: … Sequence files for all constructs should be emailed to  … several easy-to-use open source tools for converting DNA sequence files into well-formed GenBank files. ApE is an …

… there are any kind of dated references to the news, that’s why. But it was a really fun conversation. And I think … But we’re not just here to talk about us. We have a great person to talk to tonight. We have Nadine Ziemert from … it would work, but we actually found fosmids. And we sequenced the whole fosmid at the time with Sanger …

… … DAN UDWARY: Hey, everyone. I’ve got a great episode for you here today. We got the opportunity to … learned a lot so much history from this conversation about why the ocean was basically unexplored until the 70s, and … forward to seeing the data when it finally gets off the sequencers. The pandemic has obviously slowed JGI down a …

… is the podcast for you. A lot of this is based on a really great paper that came out in 2020 where this is all … least, talk to us, first about my definitions of things and why I am wrong, and also talk about some of the great … to approach it is more related to what JGI does, which is sequence genomes. And we just published last year in the …

… of challenges that usually lead to surprises and really great discoveries! And Eric’s done an awesome job, in that … you maybe explain what’s going on with their biology and why they’re so important to natural products? ERIC:  Sure. … turns a peptide, for example, from a disordered sequence into an antibiotic that kills bacteria through a …

… more than 50,000 genomes that we derived from meta-genome sequences. As always, you’ll find transcripts and show notes … scientists who also do genome mining. We’ve got a great, fun bunch of little shows lined up, and I’m really … for us– what organisms people use for genome mining, why it’s called genome mining, how the biosynthetic gene …

… enzymes are, right? ALISON NARAYAN: Yes, and so that’s why I don’t like that sentence. I think that sometimes, we … that just melts in your hands, that’s not going to be great to work with. If you have an icy, hard packed snowball … association that might help? Like, if you have an unknown sequence or new flavin monooxygenases, you could say, oh …

… capabilities and products . A minimum request of 1 Tb of sequence data is required to qualify for BERSS. For DNA … byproducts from lignin left over after biomass processing. Great Lakes Bioenergy Research Center , led by the University of …

… get a new one out every two weeks. This time, we’ve got a great interview with Ben Shen, from the Scripps Research … the paradigm of how to discover natural products. So, why I’m very excited to be working with Dan, you, with the … develop enabling technologies. ie how to translate the ATGC sequence into discrete small molecules. So, Dan, I’m very …

… stories about natural products, so you can get a feel for why I think they’re so important, and we’ll start to explain … and where we are today. After that, we have lots of great conversations that we’ve already recorded with some … more about some of the background and sort of the reasons why we want to do this. And also to provide a little more …