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    Data yielded from RIViT-seq increased the number of sigma factor-gene pairs confirmed in Streptomyces coelicolor from 209 to 399. Here, grey arrows denote previously known regulation and red arrows are regulation identified by RIViT-seq; orange nodes mark sigma factors while gray nodes mark other genes. (Otani, H., Mouncey, N.J. Nat Commun 13, 3502 (2022). https://doi.org/10.1038/s41467-022-31191-w)
    Streamlining Regulon Identification in Bacteria
    Regulons are a group of genes that can be turned on or off by the same regulatory protein. RIViT-seq technology could speed up associating transcription factors with their target genes.

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    (PXFuel)
    Designer DNA: JGI Helps Users Blaze New Biosynthetic Pathways
    In a special issue of the journal Synthetic Biology, JGI scientific users share how they’ve worked with the JGI DNA Synthesis Science Program and what they’ve discovered through their collaborations.

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    A genetic element that generates targeted mutations, called diversity-generating retroelements (DGRs), are found in viruses, as well as bacteria and archaea. Most DGRs found in viruses appear to be in their tail fibers. These tail fibers – signified in the cartoon by the blue virus’ downward pointing ‘arms’— allow the virus to attach to one cell type (red), but not the other (purple). DGRs mutate these ‘arms,’ giving the virus opportunities to switch to different prey, like the purple cell. (Courtesy of Blair Paul)
    A Natural Mechanism Can Turbocharge Viral Evolution
    A team has discovered that diversity generating retroelements (DGRs) are not only widespread, but also surprisingly active. In viruses, DGRs appear to generate diversity quickly, allowing these viruses to target new microbial prey.

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    Photograph of a stream of diatoms beneath Arctic sea ice.
    Polar Phytoplankton Need Zinc to Cope with the Cold
    As part of a long-term collaboration with the JGI Algal Program, researchers studying function and activity of phytoplankton genes in polar waters have found that these algae rely on dissolved zinc to photosynthesize.

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    This data image shows the monthly average sea surface temperature for May 2015. Between 2013 and 2016, a large mass of unusually warm ocean water--nicknamed the blob--dominated the North Pacific, indicated here by red, pink, and yellow colors signifying temperatures as much as three degrees Celsius (five degrees Fahrenheit) higher than average. Data are from the NASA Multi-scale Ultra-high Resolution Sea Surface Temperature (MUR SST) Analysis product. (Courtesy NASA Physical Oceanography Distributed Active Archive Center)
    When “The Blob” Made It Hotter Under the Water
    Researchers tracked the impact of a large-scale heatwave event in the ocean known as “The Blob” as part of an approved proposal through the Community Science Program.

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    A plantation of poplar trees. (David Gilbert)
    Genome Insider podcast: THE Bioenergy Tree
    The US Department of Energy’s favorite tree is poplar. In this episode, hear from ORNL scientists who have uncovered remarkable genetic secrets that bring us closer to making poplar an economical and sustainable source of energy and materials.

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    HPCwire Editor's Choice Award (logo crop) for Best Use of HPC in the Life Sciences
    JGI Part of Berkeley Lab Team Awarded Best Use of HPC in Life Sciences
    The HPCwire Editors Choice Award for Best Use of HPC in Life Sciences went to the Berkeley Lab team comprised of JGI and ExaBiome Project team, supported by the DOE Exascale Computing Project for MetaHipMer, an end-to-end genome assembler that supports “an unprecedented assembly of environmental microbiomes.”

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    With a common set of "baseline metadata," JGI users can more easily access public data sets. (Steve Wilson)
    A User-Centered Approach to Accessing JGI Data
    Reflecting a structural shift in data access, the JGI Data Portal offers a way for users to more easily access public data sets through a common set of metadata.

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    Phytozome portal collage
    A More Intuitive Phytozome Interface
    Phytozome v13 now hosts upwards of 250 plant genomes and provides users with the genome browsers, gene pages, search, BLAST and BioMart data warehouse interfaces they have come to rely on, with a more intuitive interface.

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    screencap from Amundson and Wilkins subsurface microbiome video
    Digging into Microbial Ecosystems Deep Underground
    JGI users and microbiome researchers at Colorado State University have many questions about the microbial communities deep underground, including the role viral infection may play in other natural ecosystems.

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    Yeast strains engineered for the biochemical conversion of glucose to value-added products are limited in chemical output due to growth and viability constraints. Cell extracts provide an alternative format for chemical synthesis in the absence of cell growth by isolating the soluble components of lysed cells. By separating the production of enzymes (during growth) and the biochemical production process (in cell-free reactions), this framework enables biosynthesis of diverse chemical products at volumetric productivities greater than the source strains. (Blake Rasor)
    Boosting Small Molecule Production in Super “Soup”
    Researchers supported through the Emerging Technologies Opportunity Program describe a two-pronged approach that starts with engineered yeast cells but then moves out of the cell structure into a cell-free system.

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    These bright green spots are fluorescently labelled bacteria from soil collected from the surface of plant roots. For reference, the scale bar at bottom right is 10 micrometers long. (Rhona Stuart)
    A Powerful Technique to Study Microbes, Now Easier
    In JGI's Genome Insider podcast: LLNL biologist Jennifer Pett-Ridge collaborated with JGI scientists through the Emerging Technologies Opportunity Program to semi-automate experiments that measure microbial activity in soil.

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    A view of the mangroves from which the giant bacteria were sampled in Guadeloupe. (Hugo Bret)
    Giant Bacteria Found in Guadeloupe Mangroves Challenge Traditional Concepts
    Harnessing JGI and Berkeley Lab resources, researchers characterized a giant - 5,000 times bigger than most bacteria - filamentous bacterium discovered in the Caribbean mangroves.

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    In their approved proposal, Frederick Colwell of Oregon State University and colleagues are interested in the microbial communities that live on Alaska’s glacially dominated Copper River Delta. They’re looking at how the microbes in these high latitude wetlands, such as the Copper River Delta wetland pond shown here, cycle carbon. (Courtesy of Rick Colwell)
    Monitoring Inter-Organism Interactions Within Ecosystems
    Many of the proposals approved through JGI's annual Community Science Program call focus on harnessing genomics to developing sustainable resources for biofuels and bioproducts.

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    Coloring the water, the algae Phaeocystis blooms off the side of the sampling vessel, Polarstern, in the temperate region of the North Atlantic. (Katrin Schmidt)
    Climate Change Threatens Base of Polar Oceans’ Bountiful Food Webs
    As warm-adapted microbes edge polewards, they’d oust resident tiny algae. It's a trend that threatens to destabilize the delicate marine food web and change the oceans as we know them.

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Home › Items tagged with: PNNL

Content Tagged "PNNL"

Page 1 of 212»

March 2, 2012

Elucidating bacteria’s roles in ant fungal gardens

Leafcutter ants cultivate fungal gardens that serve as their primary food source. Working toward the goal of harnessing novel enzymes for breaking down plant biomass to produce cellulosic biofuels, Great Lakes Bioenergy Research Center (GLBRC) researchers have been studying the process by which the fungi break down the plant leaves harvested by the ants and… [Read More]

January 13, 2012

A toolkit for T. reesei

The availability of an organism’s genome sequence is useful for improving downstream applications such as large-scale biofuel production, but it is only the first step on this path. In the case of the fungus Trichoderma reesei, whose genome sequence was published by the DOE JGI in 2008, the cellulases in T. reesei have multiple industrial… [Read More]

May 31, 2011

A.niger genome project on The Bioenergy Site

Published online ahead of print May 4, 2011 in Genome Research, a team led by Scott Baker of the Pacific Northwest National Laboratory compared the genome sequences of two Aspergillus niger strains to, among other things, better harness its industrial potential in biofuels applications. As more than a million tons of citric acid are produced annually, the production… [Read More]

May 20, 2011

Fungal lessons for large-scale “green” chemical production

The chemical compound citric acid has been produced on a large-scale basis for decades with the help of the filamentous fungus Aspergillus niger. The fungus also has enzymes that can be used to help break down plant cell walls for biofuel production, and it plays a key role in the carbon cycle. Aspergillus niger (Sue… [Read More]

March 18, 2011

Toward a Genomic Encyclopedia of Fungi

Fungi are key components of terrestrial ecosystems and help maintain the interactions between a myriad of species of animals, plants and bacteria that make up these environments. With the ability to thrive in a wide variety of ecological niches, fungi are essential to the global carbon cycle, and the enzymes and metabolites they produce are… [Read More]

October 7, 2009

Shewanella research on ScienceDaily

Researchers have completed the first thorough, system-level assessment of the diversity of an environmentally important genus of microbes known as Shewanella. Microbes belonging to that genus frequently participate in bioremediation by confining and cleaning up contaminated areas in the environment. The team of researchers from the Georgia Institute of Technology, Michigan State University and the… [Read More]

September 24, 2009

T. reesei research on ISA’s InTech

During World War II, Trichoderma reesei frustrated American Army quartermasters in the South Pacific by speeding up the rate at which canvas supplies wore out. Now the same fungus is a key producer of industrial enzymes that break down biomass for biofuel production. In 50 short years, the fungus has gone from being the bane… [Read More]

September 14, 2009

T. reesei work on MycoRant

A recent post at sciencedaily.com, Fungal Map Of Mutations Key To Increasing Enzyme Production For Bioenergy Use, discussed once again the use of Trichoderma reesei as a possible biofuel producer. This time some work at Pacific Northwest National Laboratory (PNNL) was mentioned. “We want to understand the path that we’ve taken to high enzyme production… [Read More]

September 9, 2009

Shewanella research on Environmental Protection

Researchers have completed the first thorough, system-level assessment of the diversity of an environmentally important genus of microbes known as Shewanella. Microbes belonging to that genus are used to confine and clean up contaminated areas in the environment. The team of researchers from the Georgia Institute of Technology, Michigan State University and the Pacific Northwest… [Read More]

September 7, 2009

T. reesei research on R&D Daily

Now an international team of researchers led by scientists at the DOE Joint Genome Institute (JGI), the French applied research center IFP—particularly concerned with renewable resources and energies—and the Vienna Univ. of Technology (TU Vienna) provides the first genome-wide look at what these mutations are in order to understand just how cellulase production was first… [Read More]
Page 1 of 212»

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