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… The Fungal & Algal Program explores the vast diversity of fungi and algae to unlock their potential for bioenergy, environmental sustainability, and bioproducts. By sequencing and analyzing the genomes of these organisms, the … on large-scale sequencing efforts that survey the vast phylogenetic and ecological diversity of fungi and algae, …

… Program works to uncover the roles of small molecules in biological systems, linking them with genomic data to … metabolomics fuels the discovery  of novel metabolites, genes, and proteins. It also enables exploration of energy … tools, the program supports foundational research related to soil nutrient cycling and health, terrestrial …

…   Our Sequencing Technologies Group is well-integrated across JGI departments to ensure a robust … through end-to-end automation — and further advancing sequence applications, single cell genomics, biodesign, and … [QA/QC]), large-scale liquid handling automation, and sequence analysis. …

… And at the time, it was really exciting when people would sequence [DNA]. The genome was– well, that hadn’t really … It was unpublished at that point. But people would push out gene clusters maybe once a month at most. Maybe twice a … polyketide synthase and then P3. We still don’t know why 20 years later. JACKIE WINTER: It’s pretty amazing, …

… least, talk to us, first about my definitions of things and why I am wrong, and also talk about some of the great … the active site of an enzyme. So there is no promiscuity, generally speaking, in primary metabolism. Nevertheless, … to approach it is more related to what JGI does, which is sequence genomes. And we just published last year in the …

… learned a lot so much history from this conversation about why the ocean was basically unexplored until the 70s, and … survival. Those molecules, over evolutionary time, become targeted to certain biological systems in the target … forward to seeing the data when it finally gets off the sequencers. The pandemic has obviously slowed JGI down a …

… there are any kind of dated references to the news, that’s why. But it was a really fun conversation. And I think … of it. So it wasn’t only chemistry or only biochemistry or genetics. It was also ecology. It was also evolution. It was … it would work, but we actually found fosmids. And we sequenced the whole fosmid at the time with Sanger …

… When submitting sequences to the JGI DNA Synthesis program, please include the following items: … Sequence files for all constructs should be emailed to  … several easy-to-use open source tools for converting DNA sequence files into well-formed GenBank files. ApE is an …

… the exploration of secondary metabolites across bacteria, fungi, algae and plants. These molecules, which are not … growth, provide critical advantages to the organisms producing them, and are often involved in defense, nutrient acquisition and communication. Studying how these compounds are biosynthesized and their …

… How’s it going, Eric?  ERIC:  Good. It’s an honor to be targeted by you, Dan. DAN: I’m not quite sure where to start … you maybe explain what’s going on with their biology and why they’re so important to natural products? ERIC:  Sure. … turns a peptide, for example, from a disordered sequence into an antibiotic that kills bacteria through a …

… about the basics of genome mining, which is using DNA sequence to identify and interpret biosynthetic, secondary … and BiG-SLiCE, and now the BiG-FAM database of biosynthetic gene cluster families. And he tells us about forthcoming … biological perspective, like what was this bacterium, and why did your group want to study it? Marnix Medema: You mean …

… more than 50,000 genomes that we derived from meta-genome sequences. As always, you’ll find transcripts and show notes … ALISON TAKEMURA: I know that it’s looking in the genome for genetic elements of interest, you know, something like … for us– what organisms people use for genome mining, why it’s called genome mining, how the biosynthetic gene …