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Survey of Setaria's natural diversity reveals seed dispersal in wild populations for the first time. For years, … years, farmers have selected for cereal plants without this shattering trait – referring to the moment when the cluster …

… to regulate Earth's carbon balance, to exploring the genetic basis of how plants have naturally adapted to varied … datasets to further gene function research. The  Open Green Genomes (OGG) project seeks to develop comparative … relationships as well as insights into clade-specific novelties and expansions.  … Brachypodium distachyon is an …

ALISON TAKEMURA: I know that it’s looking in the genome for genetic elements of interest, you know, something like … sequencing if you were rich enough. [CHUCKLES] And once you found a little piece of something that looked like it was a … machine learning really would help distinguish and predict novel gene clusters. DAN UDWARY: Yeah, it certainly could. …

… genomics with metabolomics fuels the discovery  of novel metabolites, genes, and proteins. It also enables exploration of energy … techniques and computational tools, the program supports foundational research related to soil nutrient cycling and …

… and BiG-SLiCE, and now the BiG-FAM database of biosynthetic gene cluster families. And he tells us about forthcoming … time called Genbiotics , which was a large program to find novel antibiotics. And this particular project focused … who share an idea, and then you extend with kind of a seed community. Maybe 10 or 20 people who are enthusiastic …

… bit more into fungi and learning the differences of all the genetic differences and then expanded on on that knowledge … seems to be a new structure, and the microorganisms are novel. I mean, we have Streptomyces , but they’re new … I think, are a good way to get people engaged and sort of seed some ideas for people in the community, I think. Also, …

… bioprospecting vs biopiracy, early stage drug discovery in general, and a possible data-driven future for plant natural … use successfully, hopefully, in the future even more so as novel therapies. And that’s how I got on that path of … new field sites. And it’s also important to set expectations because I’ve worked on hundreds of plants in …

It was unpublished at that point. But people would push out gene clusters maybe once a month at most. Maybe twice a … supposed to be orthogonal. And then we much to our chagrin found that they had the same conserved polyketide synthase … in order to put them together to build pathways, to make novel compounds, or to find analogs. And that was Warp …

… an exploration into the secondary metabolism of some more novel marine bacteria. You know, I first met Bill as a … we now know that organic molecules in the ocean are the foundation of communication by chemical means, of survival … the most effective application, of marine molecules in general. DAN UDWARY: Maybe can you explain to our audience …

… lot of like synthetic chemistry effort to create a bunch of novel compounds that actually didn’t pan out. DAN: And there … and actually get to the DNA sequence – sequences for the genes that code for the proteins that produce secondary … that came out of investigating those genes is that it was found that most biosynthetic genes are found clustered in …

… (Trillions) Operating Hours Goal Actual Total* Actual % of Goal Goal (hours)** Actual Total Actual % Goal FY 2025 … platforms. **Operating Hours target is based on 98% of the total available hours.   FY 2024 DOE Metrics There … (Trillions) Operating Hours Goal Actual Total* Actual % of Goal Goal (hours)** Actual Total Actual % Goal FY 2024 …