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… getting them out to you all. But for now, here is episode 10 of Natural Prodcast, the primer on genome mining. Hey, … Microbiomes” paper is here . Read the associated JGI news release here . Software we discussed, used for genome … reviews of genome mining: Ziemert, Alanjary, and Weber’s 2016 overview of genome mining (open access) The …

… metabolism. Hey everybody, this is Dan with episode 13 of National Prodcast. This continues our little section … a bit embarrassed that we recorded this conversation about 10 months ago. I was pretty green at the time and had some … technologies or uses or applications– are the evolutionary nature of these compounds. At the end of the day, all the …

Doering and Bryce Foster and too many others to name at JGI for the last two years or so. SMC is now released and … And you have these different types of particulate like 2.5, 10 PPMs and just the size of the particle and how far they … there a way to do that? DAN UDWARY: Well, so there’s good news and bad news on that. So one of the things that we’re …

… pairs. It was not linear, like Streptomyces , but circular. 10% of the genome encoded natural product pathways. Dan: … has been a lot of fun for us in recent years. Started in 2015, when two things happened. One, a new graduate student … still with us? Brad:  Unfortunately, not. We lost him about 13 years ago. So, I wish he was still with us because I know …

So they’re in the picomolar range. ALISON: Picomole… is [10 to the] minus twelve, right? BEN: Yeah, yeah. Well, we … company Wyeth that introduced enediynes to the market in 2001 with a drug called Mylotag. Wyeth was later acquired by … So I wanted to ask you also about – because you were in the news recently – TSRI has acquired the Pfizer strain …

… like a nice summer day in Seattle I think this was like 2013 or 2014. And antiSMASH — I know you’ve interviewed Marnix … acyl-homoserine lactone signal . mBio. 2023 Aug 31;14(4):e0101023. doi: 10.1128/mbio.01010-23. Publication: Cummings DA …

… never forced it on me, but we always had these scientific news magazines lying around at home. And I would just pick … had a high throughput screening platform where we’d look at 10,000, 15,000, 20,000 mutants a week. We started doing a … NIGEL MOUNCEY: Yeah, so we put out a strategic plan in 2018. And in building that plan, we thought about secondary …

… so there are– I hesitate to make a guess but maybe 50 to 100 different strains and they are in individual tubules.  … say a clutch is probably the size of a golf ball and has 25 to 50 eggs. I’m guessing here.  DAN: Sure, sure.  MARCY: … do when you’re exploring your systems. Because I think the JGI has a little bit of a different approach. We don’t …

… recommend David Hopwood’s book called  “Streptomyces in Nature and Medicine.” It’s obviously focused more on the … the number was. But I want to say it was like less than 10. Since, you know, a recent decade.  DAN: I’m sure that’s … me to check her stat and she was absolutely correct. Since 2010 there have been eight new antibiotics added to the …

… people what that number is. BETSY PARKINSON: So micromolar, 10 to the negative 6th. Nanomolar, 10 to the negative 9th. … what was really interesting is when I started my lab in 2018, several papers came out right in a row all about this … about 140 unique cyclic peptides. And from that, about 130 of them were not previously known. DAN: Very cool. …

… project by watching Amanda Hurley’s presentation from the 2019 JGI Genomics of Energy & Environment Meeting.] He’s also … at over 270 places now worldwide with a rate of around 10,000 students a year. And that was those numbers were … that’s really popped up at funding agencies and the popular news recently because a lot of soldiers in the Iraq and …

Celebrating 25 years of genomics research 2022 marked the JGI’s 25th … energy and environmental challenges.  Commissioned for the JGI’s 25th anniversary, the JGI mural references dozens of …