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For the first time, a team analyzes the transcriptomes of a lichen fungus and alga to understand their partnership more … glomerata . To see how gene expression changes when living together versus apart, the team grew the fungus and alga, … either separately or together, on nitrocellulose filters in Petri dishes. The scientists also sequenced the fungus and …

… maybe this is a safe place to grow because we’re all here together. ALISON: How beautiful. What a great partnership.  … a long time. But… DAN: Yeah, there are a lot of ways to put together carbon molecules. Chemistry is pretty limitless. … It’s beautiful. It looks like a bunch of colonies on a petri dish. It’s a black and white photo. It almost looks …

And so, I was working on chemically synthesizing and making derivatives of this to test its anticancer agent … cluster and a gene cluster for natural product might be all together. And so that's how we decide what we're going to … they take it home. DAN: Got it. BETSY PARKINSON: And the Petri dish. DAN: The Petri dish, they take home. And …

… also a really good friend of mine. I met him when we worked together at the late great Warp Drive Bio, a biotech startup … research-as-learning course. So they’re in the lab, they’re making discoveries, there is no like, you know, do your … of natural products research to date it has been done in a petri dish with very few media perturbations. They grow …

… of shared reactions that most living organisms share – have together. Obviously that is flawed, because it’s biology and … and accept new genes coming in and out. So, if you start making the chemistry of those organisms, then you could … are just at the stage in which synthetic biology could be making secondary metabolism more useful than before. With …

… list of things. So we have a Scripps background shared together, although I don’t think we overlapped. Kate Duncan: … this now, but when I started my PhD, I’d never poured a Petri dish. I didn’t know what a thermocycler looked like. I … or antibiotics and stuff like that. Dan Udwary: Yeah, making biofuels has to be really cost-efficient or you have …

… due to the pandemic. And she’s sleeping in our bedroom together with us still while she’s still four months old. So … come when they want to see you handle a pipet for making a nice video. Alison Takemura: Marnix, It’s just from … antiSMASH. And it’s actually quite a challenge also in making a tool that is not too easy to– for which it’s not …

… of the structures and also the challenge and thinking about making them. So I really came at it not necessarily based on … take those structures as inspirations to really start making other molecules related to those scaffolds. DAN … yellow, very fun. So in our collaboration with JGI, we put together our wish list of sequences for flavin-dependent …

The U.S. Department of Energy is committed to making its electronic and information technologies …

… with separate review schedules and selection processes, making it difficult to propose projects that truly …

… of Utah. I’ve known Eric for a long time – we worked together on Aflatoxin biosynthesis while he was a postdoc in … way, is to make a protein using the normal cellular way of making proteins, with a ribosome. Then, some other enzymes … them. Is it the animal or part of the microbiome that’s making these compounds? So in the end, we took an approach …

… most decorated and legendary natural products people– he’s making a face. Talking to us today is Bill Fenical from … settled there as well, as a faculty member. But we were all together. There was even a degree of, I would say, … And we followed cultivations. We set up a library of Petri plates to watch what happens over time. And in the …