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… metabolomics fuels the discovery  of novel metabolites, genes, and proteins. It also enables exploration of energy … molecules function within plants, microbes, and ecosystems. Identifying and analyzing primary and secondary metabolites … scientists are able to link metabolic activity with gene expression, providing deeper insights into functional …

… with other organisms, and adapting to environmental changes. The program lays the groundwork for sustainable … to regulate Earth's carbon balance, to exploring the genetic basis of how plants have naturally adapted to varied … Centers. The  Plant Gene Atlas initiative develops gene expression catalogs across JGI Plant Flagship …

… single-cell and spatial transcriptomics barcode-based genetics (RB-TnSeq), and computational genomics to better … strains, whereby they can modulate host metabolism, gene expression and phenotype. We have recently identified … model system. We seek to expand beyond this model system by identifying phages and characterizing this multipartite …

It was unpublished at that point. But people would push out gene clusters maybe once a month at most. Maybe twice a … if you want– if you really want to, you can do heterologous expression. You can do homologous expression techniques and … of matter that are even marginally better, then that changes the game. And you can reopen the book and come up …

… growth, provide critical advantages to the organisms producing them, and are often involved in defense, nutrient … conditions, with only a small portion of the biosynthetic gene clusters (BGCs) being expressed. The program works to … pathway analysis, optimization of cell- and cell free-based expression platforms, tools and data for deciphering …

… for another episode of Natural Prodcast. Right now I’m working on this the afternoon of the day I’m due to release it, … and he has a project with the JGI to synthesize the genes for and explore the chemistry of quorum sensing … of these or any organisms. So developing good heterologous expression hosts like maybe in many fields now like in …

… and BiG-SLiCE, and now the BiG-FAM database of biosynthetic gene cluster families. And he tells us about forthcoming … was a proposal on synthetic biology of engineering gene expression in bacteria – however, the professor was actually … is definitely the most comprehensive set of tools for identifying gene clusters. There’s nothing that is quite as …

… led by researchers at the University of Texas (UT) at Austin, the HudsonAlpha Institute for Biotechnology … of switchgrass and is a key component in providing genetic variation available for selection to improve biofuel … grasses have and will use to respond to climate shifts. Changes in ploidy might play a key role in this response. …

DAN UDWARY: You’re listening to the Department of Energy Joint Genome Institute’s … ALISON TAKEMURA: I know that it’s looking in the genome for genetic elements of interest, you know, something like … want to explain that to someone who doesn’t know much about genetics or anything else, science wise maybe, what genome …

The JGI has diverse capabilities in: DNA and RNA sequencing, Sample and library preparation, … percentile*) DNA Synthesis Constructs <5kb in size Single gene or multiple small genes assembled to less than 5kb in … alignment files 384/454 Fungal Transcriptome RNA for expression profiling and genome annotation (single …

… for Episode 14 of Natural Prodcast . There’s been a lot going on, so I took a little break, but I’m hoping that from … my undergraduate in microbiology and then PhD in microbial genetics in the UK. And came across to the US for a couple … explore the regulation of biosynthetic gene cluster expression in organisms. And that’s led by Hiroshi Otani …

… about natural products. So in Brad’s lab, I worked on identifying and characterizing haloperoxidases from … bit more into fungi and learning the differences of all the genetic differences and then expanded on on that knowledge … it was amazing. And now you have– just to the exponential expression of all these genomes and what can happen with all …