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… & Algal Program explores the vast diversity of fungi and algae to unlock their potential for bioenergy, environmental … is a five-year project to sequence 1000 fungal genomes from across the Fungal Tree of Life, from an international … team in collaboration with the JGI. Conserved Fungal Genes of Unknown Function offer a collection of fungal genes …

… such effort is targeted at environmental cells that are from candidate phyla, major branches in the phylogenetic … (2017). Woyke T . & Rubin E.M. Evolution. Searching for new branches on the tree of life. Science. 346:698-9 (2014). … Z. & Rubin E.M. Metagenomic discovery of biomass-degrading genes and genomes from cow rumen. Science 331, 463-7 (2011). …

… of secondary metabolites across bacteria, fungi, algae and plants. These molecules, which are not essential … and their roles in the environment, can unlock new avenues for bio-based products and bioenergy crop … interactions with their environments and with each other, from defending against predators to aiding in symbiotic …

… research is focused on the discovery and characterization of novel bacterial, archaeal and eukaryotic microbes and … and phylogenomics) and machine learning to identify new divergent lineages and expand the Tree of Life. We then … in cell biology. 25 (6), 339-346 Schulz et al. (2015) Marine amoebae with cytoplasmic and perinuclear symbionts …

DAN: Welcome back to Natural Prodcast! This is episode 4! From here on out, for a while, we’re going to be presenting … example of probing fungi for natural products and finding new things. And so, really happy to have you here. And … with. So transformation, or manipulation of the DNA of genes and bacteria, occurred much faster earlier than they …

… real legends of natural products, Professor Bill Fenical from Scripps Institution of Oceanography in San Diego. Bill is a pioneer of marine natural products, getting into the ocean and looking … then of course using modern phylogenetic tools measuring genes, the 16S gene, and comparing it with everything that’s …

… genome mining on more than 50,000 genomes that we derived from meta-genome sequences. As always, you’ll find … in most fungi, biosynthetic gene clusters, which are the genes that do the biosynthesis of a secondary metabolite, … come from all kinds of disparate environments. There’s some marine. There’s some soil samples. There’s human gut …

… you’ll be hearing about microbiology and natural products from the Great Salt Lake, and you’re going to learn, like … just not enough time and money. I mean, we have a huge marine fungal project in collaboration with Bill Fenical at … organisms actually have quite a few antibiotic-resistant genes in there. And so we’re trying to use those as …

… week, we have our conversation with Professor Eric Schmidt, from the University of Utah. I’ve known Eric for a long time … make that make sense as an acronym, but there you go. A tiny bit of background on this: Most of the machinery in any … really need to know how they’re made. You need to bring the genes into the lab, and you need to manipulate them in the …

… working with him.  We talk about his father, the legendary marine natural products chemist, Richard Moore, and get into … the University of Hawaii and moved there in the early ’60s from Berkeley to work on this new budding field of marine … genomics existed. This is before we’re even thinking of genes and connecting genes to molecules, which is something …

The CSP New Investigator Call is for investigators and research initiatives new to the JGI. Projects must be independent of ongoing JGI proposals, and lead PIs cannot have been lead …

… we get to present our conversation with Marnix Medema , from Wageningen University in the Netherlands. Marnix is … work. And that it involves some of these crazy genes, some of these enormous genes that encode these very … that time. Dan Udwary: So we should probably just back up a tiny bit and just say what antiSMASH actually is and does. …