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… in 2020 where this is all explained in detail, so if you’d like a link, just check out the show notes above or at … to find any new genomes, new areas or regions or loci, that encode for new, truly chemical dark matter BGCs. That’s the … URI. “ The evolution of secondary metabolism – a unifying model” “ Natural products – a simple model to explain …

… miners use, including antiSMASH, MIBiG, and newer efforts, like BiG-scape and BiG-SLiCE, and now the BiG-FAM database … of these crazy genes, some of these enormous genes that encode these very large enzymes. And I was like, OK, wow, … I think this is really– I personally like this really as a model for a collaboration. You have your code as open source …

… to Natural Prodcast! This is episode 4! From here on out, for a while, we’re going to be presenting some conversations … products researcher from the University of Wisconsin. Like we discussed in the primer podcasts ( part 1 here , … more interested just to see if we can use Aspergillus as a model for expressing hard to work with eukaryote [genes]. So …

… or reaching out on Twitter to @JGI or me @danudwary. Like I said in the intro to the first episode , after this … there had been lots of exploration of the genes that would encode secondary metabolism. People wanted to understand … to go ahead and, and synthesize those genes within a model organism like E.coli , and have it produce the …

… about natural products you’ll get a good sense of what it’s like working with him.  We talk about his father, the … and SIO. Oh, I should say what those are. Brad: What’s SIO, for all those listeners out there? Dan: Scripps Institution … linear, like Streptomyces , but circular. 10% of the genome encoded natural product pathways. Dan: Yeah, that’s kind of …

… bucket. [LAUGHS] I don’t know that that’s ever necessarily like a good description of anyone because chemistry means a … think might be happening, we’re sort of converging on this model of this being called an egg defense model. And so … be able to find genes in the organism in its sequence that encode for that biosynthesis. But sometimes you have to know …

… … DAN: Hey, everybody. Welcome back for another episode of Natural Prodcast. Right now I’m … hear about something I’ve been working on for what feels like forever, and we also recorded a proper introduction … if you have a quorum sensing system or the genes that could encode for that right next to a larger biosynthetic gene …

… of secondary metabolism.  DAN: Hey there and welcome back for Episode 8 of Natural Prodcast. This week, we have our … in the old days, saw how hard it was – it felt kind of like training for a marathon by running at a high altitude! … And a lot of us moved on to work in simpler systems, like bacteria, where we figure we can make more progress …

… the series of interviews we recorded at the Society for Industrial Microbiology and Biotechnology (SIMB) Natural … can I make that big, beautiful molecule? And so I’d like to think I’ve evolved a bit since that time. And I … shows the pyramidalization of phosphines and predictive models that allow you to choose the right phosphine ligand …

… and scientists of secondary metabolism. Welcome back for our second season of Natural Prodcast. This first … for genetic elements of interest, you know, something like treasure. DAN UDWARY: There you go. ALISON TAKEMURA: It … of a gene that you knew was probably biosynthetic that encoded for some secondary metabolism, then you would …

Marc was the Head of Experimental Genomics there, before he decided to leave for graduate school and pursue his … having me. DAN: We know each other pretty well. So I feel like it’s always fun to talk to you. I’m particularly … and antibiotic activity, and it fits pretty well a model that was developed for macro organisms like rabbits …

… sequencing, synthesis, and targeted metabolomics support for DOE-BER funded awards, including awards funded through  … in the BER funding call, proposals are NOT eligible for BERSS support through the JGI (with the exception of … Berkeley National Laboratory: This center concentrates on “model” crops of rice and Arabidopsis, in the search for …