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2022 Progress Report
Pictured is a timelapse of the Integrative Genomics Building (IGB) seen above is … Area are also co-located in the IGB. Vision The vision of the U.S. Department of Energy (DOE) Joint Genome Institute (JGI), a DOE Office …
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Uri Neri
… just "spicy messenger RNA", and that somewhere in the mess of genetic sequences lurks the next cool virus – if only our code would …
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JGI Accepts 17 Proposals for Community Science Program
Interactions Within Ecosystems Latest portfolio of approved proposals highlight biodiversity and how ecosystems are adapting to stresses. A total of 17 proposals have been approved through the annual … collaboration that produced the reference genome sequence for Eucalyptus grandis. Accessing recently burned …
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Consensus statement from the first RdRp Summit: advancing RNA virus discovery at scale across communities
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Boosting Small Molecule Production in Super “Soup”
… still work in cell-free environments? (Spoiler: Yes.) Think of cells as tiny factories: within their walls they have … , researchers led by Hal Alper at The University of Texas at Austin and Michael Jewett of Northwestern … are partnering with Yasuo Yoshikuni and Ian Blaby of the DNA Synthesis Science Program . “This collaboration brings …
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Busting the Unbreakable Lignin
New evidence shows anaerobic fungi can degrade the hardiest of plant components   The Science There are three main … called lignocellulose, are the primary components of hardy cell walls. It’s the cellulose and hemicellulose … shows how anaerobic fungi — the kind living in the stomachs of livestock — are actually capable of naturally modifying …
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Endogenous short RNAs generated by Dicer 2 and RNA-dependent RNA polymerase 1 regulate mRNAs in the basal fungus Mucor circinelloides
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Analysis of 4,664 high-quality sequence-finished poplar full-length cDNA clones and their utility for the discovery of genes responding to insect feeding
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Computationally Classifying Fungal Lifestyles
Machine learning methods were applied on sequenced fungal genomes to classify gene families. The Science As a proof of concept, researchers developed an algorithm that … Laboratory (Berkeley Lab), has generated a more accurate phylogenetic tree tracking the evolution of  Dothideomycetes …
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JGI Workshop at SIMB NP Meeting
Metabolism   Although there are still a large number of secondary metabolites yet to be discovered and their … accessing these untapped metabolic capabilities is often tedious and resource intensive. This is often due to, … expressing a given BGC in various hosts, availability of sequenced genomes, and computing resources needed to predict …
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You Can Move, But You Can’t Hide
… to replicate themselves and spread from cell to cell. Two of the most common forms of MGEs are viruses and plasmids. They can be found in … MGEs based upon their gene content and their genetic sequences. The software was created by researchers under the …
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Fishing for Novel Cellulose Degraders
… genomic approach to bioprospecting. The Science One of the most vital pieces of equipment for fly fishing is a boxful of lures. Designed … cellulases from their captured genomes, the team then used DNA synthesis and cloning, followed by protein in vitro …
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