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A Better Way to Find RNA Virus Needles in the Proverbial Database Haystacks
… Team develops a computational pipeline to sift and … said Eugene Koonin, a senior investigator at the NCBI and one of the senior authors on the paper, of the uncovered … analyses – as best we could, we tried to describe the protein domains every virus carries, and who is their likely …
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Single-cell genomics of co-sorted Nanoarchaeota suggests novel putative host associations and diversification of proteins involved in symbiosis
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Novel Hydrophobins from Trichoderma Define a New Hydrophobin Subclass: Protein Properties, Evolution, Regulation and Processing
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Crysten Blaby-Haas
… Dr. Blaby-Haas joined the JGI in 2022 as lead of the Biomolecular … Molecular Foundry for genome-encoded biomaterial discovery, design, and engineering. She earned her PhD in Microbiology … expanding her experimental repertoire to include in vitro protein-based techniques, algae, and plants, while focusing …
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DOE Metrics
… FY 2026 DOE Metrics Sequencing Quarter Total Bases (Trillions) Operating Hours Goal  Actual … hours. Other DOE Quarterly Metrics Q1 – Report on new computational developments for improving microbial, … or plant genomes. [Download PDF] End-of-year Goal – Develop one new computationally enabled approach to analyze complex …
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Tracking the Origins of Methane-Producing Microbes
… Mini-Metagenomics Approach Helps Identify Novel Archaeal Methane Metabolism. Methane-producing archaea … on the global carbon cycle. All methanogenic archaea use one of three pathways for methanogenesis: hydrogen-dependent … The JGI provides integrated high-throughput sequencing and computational analysis that enable systems-based scientific …
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Boosting Small Molecule Production in Super “Soup”
… production process (in cell-free reactions), this framework enables biosynthesis of diverse chemical products at … walls they have both the machinery to make products such as proteins, and the mechanisms for maintenance to keep … have been really powerful at finding ways to accelerate bio-design and identifying the best sets of enzymes that enable …
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Entities inside one another ‐ a matryoshka doll in biology?
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Diel rewiring and positive selection of ancient plant proteins enabled evolution of CAM photosynthesis in Agave
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Adam Reisselman on being a 2016 DOE Computational Science Graduate Fellow
… The Department of Energy's Computational Science Graduate … worked with DOE JGI's Sam Deutsch. Learn more about the DOE Computational Science Graduate Fellowship Program at …
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JGI@25: The Little Alga That Could
… the project was co-led by Daniel Rokhsar, head of the JGI’s Computational Biology Program, along with JGI Computational … sequences have been cited in almost one-fourth (23.8%) of publications focused on that specific algae. The reference … within Chlamy, meaning that its RNA can produce up to four proteins, which has far-reaching implications. “This is …
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Microfluidic-based mini-metagenomics enables discovery of novel microbial lineages from complex environmental samples
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