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Extracting the Secrets of Secondary Metabolites
… molecules not essential for growth yet essential for survival, may now be easier to characterize following a proof-of-concept study in which researchers paired CRISPR and CRAGE technologies. While CRISPR (Clustered Regularly … User Facility, is supported under contract DE-AC02- 05CH11231. …
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Nikos Kyrpides
… Genome Institute in 2004 to lead the Genome Biology Program and the development of the comparative analysis platforms for microbial genomes and metagenomes (IMG). He became the Metagenomics Program head in 2010 and … BA in Biology, Aristotle University of Thessaloniki, Greece PhD in Molecular Biology and …
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JGI Workshop at SIMB NP Meeting
… Jan. 7: New Capabilities to Study Secondary Metabolism   Although there are still a large number of secondary metabolites yet to be discovered and their biosynthetic logics to be understood, …
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Natural Prodcast Episode 17: Cassandra Quave
… Dan Udwary: Hey everybody! Welcome back for Natural Prodcast episode 17. The … than HIV/AIDS does every year in the US and it has since 2005 even though we technically have a number of different … I think on COVID that we’re getting ready to submit for publication and have found some interesting hits for that as …
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Game On: High School Students Drive Everglades Metagenomics Study
… a conference in Florida to discuss a JGI pilot project involving soil sampling in the Florida Everglades to help … for the JGI’s Integrated Microbial Genomes & Microbiomes (IMG/M) portal for their sample analysis.  The class had to … and organic carbon concentration. From Field Studies to Publication Together as a class, the students learned about …
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Uncovering secondary metabolite evolution and biosynthesis using gene cluster networks and genetic dereplication
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Evolution of a Fungal Gene Expression Regulator
… Describing the largest analysis to date of the modified DNA base 5mC variations in fungi. The Science Changing an A, C, T or … of the US Department of Energy under contract no. DE-AC02-05CH11231. The Georgia Advanced Computing Resource Center (GACRC) and Georgia …
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The Sorghum bicolor reference genome: improved assembly, gene annotations, a transcriptome atlas, and signatures of genome organization
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Soil virus offers insight into maintaining microorganisms
… Using the IMG/M data portal, researchers have identified a virus protein tied to carbon cycling.  The … Lawrence Berkeley National Laboratory (Berkeley Lab). Using 5,000 images of crystalized samples cloned and synthesized … the Department of Energy (DOE) Office of Biological and Environmental Research (BER) and is a contribution of the …
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Ecological generalism drives hyperdiversity of secondary metabolite gene clusters in xylarialean endophytes
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Genome organization of the vg1 and nodal3 gene clusters in the allotetraploid frog Xenopus laevis
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A Collaboration to Improve Plant Genome Annotations Across Species
… To provide broad plant genomic capabilities, the DOE Joint Genome Institute … Gene Atlas in  Nucleic Acids Research . The project spans 15 years and involves more than 17 research groups. The team …
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