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Plant Microbial Interactions Group
… are complex organisms that harbor a fantastic diversity of cell types and associated organisms, including fungal and … and are influenced by microbial partners. We use a variety of genomics-powered tools to study this complexity, … fungi, viruses. Resident viruses can be found in a myriad of bacterial strains, whereby they can modulate host …
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JGI Early Career Researchers Featured in mSystems Special Issue
… In a special issue of mSystems , out May 14, 2019, JGI researchers are among … article, Micro-Scale Applications head Rex Malmstrom and Metagenome Program head Emiley Eloe-Fadrosh outline more … aided by genome assembly from metagenomes. This is a critical step toward better understanding the impact of …
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A Community Resource for Secondary Metabolite Researchers
… user engagement. The Science In addition to the core set of "primary metabolites"—chemical compounds shared by most … more than 13 million BGCs in the catalog at the time of publication, it is the largest repository of BGC sequence … and secondary metabolites information from isolate and metagenome data.   The SMC ( smc.jgi.doe.gov ) is designed …
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Toward More Reproducible, Reusable Stable Isotope Probing Experiments
… communities than ever before — especially with the prospect of meta-analyses boosted by AI and Machine Learning — JGI … from this group, as well as feedback from researchers around the world, the team have now published a  Minimum … easier to compare?” said Malmstrom, who worked with JGI Metagenome Program head Emiley Eloe-Fadrosh to host …
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Mining Public Databases Yields Largest Map of Fungal Mitochondrial Genomes to Date
… genome data, unlocking new potential for AI-driven studies of energy metabolism. The Science Researchers produced … size and structure varied enormously, ranging from just 12 kilobases in Rozella allomycis , an early-diverging … First, they scanned over 26,000 publicly available metagenomes in the JGI's IMG portal for mitochondrial …
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Accelerating Metagenomics Discoveries with Deep Learning
… insights from metagenomic data. In deep learning, a branch of machine learning, data is passed through algorithms … into multiple interconnected layers. The architecture of these algorithms, inspired by communication networks … found in nature, allows machines to “learn” features. State of the art algorithms can perform astonishing degrees of …
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Exploring and Thinking Critically about Scientific Problems with JGI Interns
… they constantly collaborated with each other on new ways of presenting and researching science. …
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Mining Metagenomes for Cas Proteins
… Institute.  The Science Researchers report the discovery of miniature Clustered Regularly Interspaced Short … acids (aa) in size, half that of previously known class 2 CRISPR enzymes that are typically 950—1400 aa. They were … metagenomic datasets from a wide variety of ecosystems around the world, conducting iterative searches using …
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How to Target a Microbial Needle within a Community Haystack
… A workflow for capturing the genetic make-up of specific uncultivated microbes from complex environmental … allow researchers to focus on specific microbes within metagenome samples and associate their sequences with their … probes, so the signal amplification provided by HCR-FISH is critical for detection. Once cells are labeled with …
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Plotting a Model for Virus-Host Warfare Deep Below Ground
… Science Altiarchaea are carbon-fixing microbes and targets of multiple viruses in Earth’s deep subsurface. They are … in oxygen-poor environments without oxygen deep below ground. These archaea fix carbon and nitrogen, but the … do so, they compared samples collected from an aquifer in 2012 and 2018 against a biofilm sample collected in 2018. …
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Metagenomics
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High-Throughput Translational Medicine: Challenges and Solutions
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