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… then I contacted a number of PIs, and in the end, I think 80 research groups from around the world contributed with, … for a while. Version 5 has been around for a bit. Version 6 is on the way, I hear? You just said. So antiSMASH is … field, many people had just been looking at like 16S taxonomic profiles of these communities looking at who is …

… at the University of Hawaii and moved there in the early ’60s from Berkeley to work on this new budding field of … Brad: Yeah, for sure. So we’re going back to the mid-late ’80s. And at that time, you know, it’s before genomics … vehicles. Brad: You did not! Alison: I did, like 2016, I think. Yes, it was just so funny to hear how they’re …

And I thought, well, I know that we can do this. So in 2006 was when I started our cave-based natural product … of thing. But it’s a lot of work. So to me, to us, about 6 years ago, we thought the big gap in genome mining is not … you could look at metabolism markers like phosphoprotein S6. So if there is a perturbagen present– DAN UDWARY: …

… learn as much about it as possible starting with we picked 183 of them. And we sent that list to the Joint Genome … signal . mBio. 2023 Aug 31;14(4):e0101023. doi: 10.1128/mbio.01010-23. Publication: Cummings DA Jr. Methylotroph … Stable Isotopic Labeling . ACS Chem Biol. 2021 Aug 20;16(8):1332-1338. doi: 10.1021/acschembio.1c00329. …

… but traditionally, somewhere in the neighborhood of 60 to 70% of all of the medicines that we use are natural … 2000. As you can see, from the 1940s, into the 50s into the 60s, there was a huge growth – a huge explosion in new …