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… welcome back to Natural Prodcast, and this will be episode 11. This continues our little sprint on genome mining. In the … talk and that now I can bring it to you. So enjoy, episode 11 of Natural Prodcast. Alison Takemura: Marnix, where are …

… pairs. It was not linear, like Streptomyces , but circular. 10% of the genome encoded natural product pathways. Dan: … Brad: Yeah, at that time, that was new, right? Like, my god 10% of the genome makes small molecules that have, you know, … of changed over the years. And I think maybe over the last 10 years, I’ve really become a fan of having postdocs, and …

… JGI and the Molecular Foundry.  Submission Deadline Feb 19, 2026 (Proposals due 4/30/26) April 9, 2026  11:59pm PT  Sep 8, 2026 Jan 29, 2027 March 31, 2026 …

… And I set that up. And we finally got that to work 10 years later. But in the meantime there, we had people … a teaspoon of soil from outside, you maybe have to do a 10,000-fold dilution to plate that out. The deeper you go in the cave, the less dilution. You can be down to 1 on 100 in a deep portion of a cave. So it just– it really, …

… like a nice summer day in Seattle I think this was like 2013 or 2014. And antiSMASH — I know you’ve interviewed Marnix … learn as much about it as possible starting with we picked 183 of them. And we sent that list to the Joint Genome … 2021 Aug 20;16(8):1332-1338. doi: 10.1021/acschembio.1c00329. …

… who was working on these things in the very early 1900s.  DAN: And so he has drawn what he called … molecules and their discoveries over a stretch from 1940 to 2000. As you can see, from the 1940s, into the 50s …