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… welcome back to Natural Prodcast, and this will be episode 11. This continues our little sprint on genome mining. In … to tell a quick story. Looking back, the year was probably 2010, 2011, I was a, uh- actually, I’ve got the t-shirt on … that you do, then it’s very easy to think that, OK, I find 25 gene clusters, there must be 25 new compounds. Or …

… because I was always swimming or surfing. And you know, 25 hours a day we’re at the beach practically. It was just – … pairs. It was not linear, like Streptomyces , but circular. 10% of the genome encoded natural product pathways. Dan: … has been a lot of fun for us in recent years. Started in 2015, when two things happened. One, a new graduate student …

… JGI and the Molecular Foundry.  Submission Deadline Feb 19, 2026 (Proposals due 4/30/26) April 9, 2026  11:59pm PT  Sep 8, 2026 Jan 29, 2027 March 31, 2026 Review …

… just did a low-resolution shotgun pass where we sequenced 500 runs. And then we used those to find gene clusters in … And I set that up. And we finally got that to work 10 years later. But in the meantime there, we had people … be difficult to write a grant on right now like another P450 or glycosyltransferase. You probably would have a hard …

… like a nice summer day in Seattle I think this was like 2013 or 2014. And antiSMASH — I know you’ve interviewed Marnix … an unusual acyl-homoserine lactone signal . mBio. 2023 Aug 31;14(4):e0101023. doi: 10.1128/mbio.01010-23. Publication: Cummings …

… who was working on these things in the very early 1900s.  DAN: And so he has drawn what he called … molecules and their discoveries over a stretch from 1940 to 2000. As you can see, from the 1940s, into the 50s into the 60s, there was a huge growth – a huge explosion …