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JGI Workshop at SIMB NP Meeting
… and their biosynthetic logics to be understood, accessing these untapped metabolic capabilities is often tedious … expressing a given BGC in various hosts, availability of sequenced genomes, and computing resources needed to predict BGCs from available genome sequences. The DOE Joint Genome Institute (JGI), a DOE …
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Uri Neri
Neri is a computational biologist who spends his days wrangling viral genomes and occasionally remembering to document his code. At JGI, he develops tools for … messenger RNA", and that somewhere in the mess of genetic sequences lurks the next cool virus – if only our code would …
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Expanding Virophage Diversity
… are small viruses with double-stranded DNA genomes that co-infect eukaryotic cells along with giant viruses. Virophages … increased the number of known high quality virophage genome sequences 10-fold through computational approaches. By … they were able to identify 44,221 total virophage partial sequences, including over 28,000 unique MCP sequences.  …
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Ancient Algae Reveal Secrets of Plant Evolution
… land over 600 million years ago. The Science By studying the genes of land plants’ closest algal relative,  … Berkeley National Laboratory (Berkeley Lab), scientists sequenced the genomes of four  Zygnematophyceae algae, which … plant resilience and productivity. The algal genomes sequences are available on the JGI’s  PhycoCosm portal. … …
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An Age of CRAGE: Advances in Rapidly Engineering Non-model Bacteria
A group led by JGI scientists have made strides in improving and applying a method that allows researchers to quickly … domesticate some 60 strains, inserting into them a genetic sequence that acts as a “landing pad.” Mouncey adds, “Once …
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Applying Viral Genomics Expertise to Understanding the Human Virome
… tools and data hub for NIH program. While the microbes in, on and around Earth outnumber the stars in the Milky Way, viruses outnumber the microbes by at least … collection of UViGs by identifying contiguous viral sequences (“contigs”) from thousands of ecologically diverse …
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A Revamped Amplification Method that Enables Nearly Complete Single-Cell Genomes
With a new methodology, scientists are now getting more complete genomic results from single cells. The … Amplification to generate enough DNA to put on a sequencer. As previously mentioned, it’s a method that’s … assembly. So while researchers are confident all the DNA sequences came from one cell, including components like …
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Researching and Solving Real-World Problems with the 2023 JGI-UC Merced Interns
For the first time in several years, the DOE Joint Genome Institute hosted several UC Merced students this … mentor Bryce Foster, Benchmarking Bioinformatics Tools for Sequence Similarity Searching Morgan Lavenstein Bendall and …
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Cataloging the Microbes that Manage the Health of River Systems
Database provides details on river microbes in 90% of US continental watersheds. The Science In a recent Nature paper , … program at Pacific Northwest National Laboratory. The JGI sequenced over 1,000 metagenomes and established …
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Game On: High School Students Drive Everglades Metagenomics Study
In late June, Kathleen Lail, a member of JGI’s Sample … samples to the JGI for sequencing.  While JGI processed, sequenced, and analyzed the soil samples, the JGI offered 7 … and Proteobacteria to be the most common phyla of bacteria sequenced from the metagenomic soil samples from the four …
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Methane Makers in Yosemite’s Lakes
… (a marmot!) as they’ve sampled the microbial communities living in the mountaintop lakes of the Sierra Nevada mountains. These lakes are …
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Ray Turner Completes Last Tour of Lab Duty at JGI
… last 15 years, Ray Turner has been one constant for the Joint Genome Institute. On July 1, 2020, that all changed. Ray’s vigilant … last 15 years, Ray Turner has been one constant for the Joint Genome Institute. On July 1, 2020, that all changed. …
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