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… sgRNA sequences: six for every gene in the genome. The JGI  DNA Synthesis Science team synthesized these sgRNAs, cloning … in a  Y. lipolytica strain lacking a necessary enzyme for DNA repair. Whereas an effective sgRNA would lead Cas9 to make a lethal double-strand DNA break, a dysfunctional sgRNA would be harmless. The team …

… a combination of biology and computer science, to reveal clues about how microbial and bacteria communities … work on this project was only the beginning of this much longer-term body of work, the experience helped to solidify …

… a plant. The Science Sex in plants can be befuddling. Most species are hermaphrodites, expressing both male and female … i.e., XY instead of XX. But, like some plant and songbird species, the system in shrub willow is flipped: females are … … This work was supported by the NSF Dimensions of Biodiversity Program (DEB-1542509 to S.D., DEB-1542486 to LBS, …

As mobile genetic elements like viruses spread their DNA, they can affect how microbes cycle nutrients and adapt …

… certain diseases are well known to be partially due to the DNA sequence that makes up an individual’s genome. The genes …

But to see what they’re doing, he first needs their DNA.   …

… to become an essential tool for researching global viral diversity. geNomad has already been downloaded thousands of …

… et al (2022) Wildfire-dependent changes in soil microbiome diversity and function.  Nature Microbiol. 7(9):1419-1430. … et al (2019) Transcriptomic atlas of mushroom development reveals conserved genes behind complex multicellularity in … Haitjema et al (2017) A parts list for fungal cellulosomes revealed by comparative genomics.  Nature Microbio 2:17087. …

… the genomes of two varieties of a close relative and model species. The following year saw the beginnings of common … decades of research, switchgrass has become an important species whose complex genomes are helping breeders …

… both the 50th celebration of Earth Day on April 22, and DNA Day on April 25. As both Earth and DNA are close to our JGI hearts, we’re highlighting genomic …