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DAP-seq Drives Robust Mapping of Gene Regulation
… and adaptation.    Understanding how genes are regulated is like deciphering the complex wiring behind a city’s power … where transcription factors (TFs) — the proteins that flip genetic switches — bind DNA were limited to a few model … species, illuminating thousands of regulatory “switches” within multiple complex genomes. The end product is an …
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Researching and Solving Real-World Problems with the 2023 JGI-UC Merced Interns
… Joint Genome Institute hosted several UC Merced students this past summer. This year’s cohort for the JGI-UC Merced … Pathogens Shayna Bennett and mentor Robert Bowers, Mobile Genetic Elements and CRISPR Spacers in the Conifer Needle … : So while here at the JGI, I’ve been studying mobile genetic elements and CRISPR spacers in the conifer needle …
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Toward More Efficient Artificial Photosynthesis
… are the factories in plant cells. Using photosynthesis, they take raw materials including sunlight, carbon and water, to convert them into energy that is then stored. A team led by researchers at the Max Planck … have developed a platform that mimics chloroplast function within a cell-sized system. The Impact Photosynthesis …
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Team Science Reveals Important Protein in Poplar
… potential for engineering bioenergy crops The Science Scientists at Brookhaven National Laboratory (BNL) led a team that  identified a protein , PtrbHLH011, within poplar involved in plant growth, lignin production, and disease resistance.  The Impact With increased lignin and …
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An Addiction Crucial to a Fungus’ Reproduction
… The Science To better understand how beneficial organisms (symbionts) are transmitted between host generations, … researchers investigated the role that bacteria living within a host (endosymbionts) have on fungal host … they regulate. The bacterial endosymbiont, Burkholderia , is recognized as a mutualist, where both species of organism …
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2022 Progress Report
… Pictured is a timelapse of the Integrative Genomics Building (IGB) seen above is home to the DOE Joint Genome Institute (JGI). Researchers … Lab Biosciences Area are also co-located in the IGB. Vision The vision of the U.S. Department of Energy (DOE) …
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Webinar: PhycoCosm Tutorial
… sequenced algal genomes, omics data and comparative analysis tools. Questions and Answers 1.  Q(uestion): Why would … us and we’ll work work it out 2.  Q(uestion): Do you publish the data sets the trees are based upon? A: This is still work in progress as new genomes are being added. …
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Toward More Reproducible, Reusable Stable Isotope Probing Experiments
… on these advances. Over the last two decades, Stable Isotope Probing (SIP) has opened vast windows into specific … researchers to go beyond understanding which microbes are present in a sample, to generate data about which organisms … Knowledgebase (KBase), as well as researchers from Pacific Northwest National Laboratory, Northern Arizona University, …
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JGI@25: Fueling Investigation into Methane-Making Microbes
… In honor of the JGI's 25th anniversary in 2022, we have revisited a number of notable achievements that showcase our … help solve energy and environmental ch allenges. Methane emissions are a massive factor driving climate change. … livestock — specifically, from the methane-making microbes within their rumen. There is another climate-minded reason …
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Engagement Webinar: Utilizing long-read sequencing for metagenomics and DNA modification detection
… This webinar focused on how the JGI employs single-molecule, … to aid with genome assembly and transcriptome analysis of microbial, fungal, and plant research projects.  More … PI. We currently use the ‘Base Modification Analysis’ tool within PacBio SMRT link, which works well for 6mA and 4mC …
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Defining a Pan-Genome for Antarctic Archaea
… Analysis of haloarchaeal metagenomes broadens understanding of Antarctic biogeography. The Science Haloarchaea flourish in hypersaline environments, and researchers are … a haloarchaea “pan-genome.” Described as the total pool of genetic material comprised by all members of a species, the …
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A Revamped Amplification Method that Enables Nearly Complete Single-Cell Genomes
… With a new methodology, scientists are now getting more complete genomic results from … cells. The Science Studying the  genomes of microorganisms is incredibly useful for understanding the microbiome … it’s difficult to link the connections to them from the genetic elements that scientists have found, e.g. plasmids …
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