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Len Pennacchio
… In 2003, Dr. Pennacchio joined the DOE Joint Genome Institute and has focused on applying state-of-the-art molecular methods to address wide-ranging … Pennacchio received his Ph.D in 1998 from the Department of Genetics at Stanford University where he uncovered the …
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The Surprising Structure of a Shrub Willow Sex Chromosome
… A genetic architecture that is characteristic of the sex … some, including shrub willow  Salix purpurea , employ the evolutionary strategy we are far more familiar with: … This work was supported by the NSF Dimensions of Biodiversity Program (DEB-1542509 to S.D., DEB-1542486 to …
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Boosting Small Molecule Production in Super “Soup”
… still work in cell-free environments? (Spoiler: Yes.) Think of cells as tiny factories: within their walls they have … ways to accelerate bio-design and identifying the best sets of enzymes that enable synthesis of sustainable … (BDO). To do so, the yeasts received fine-tuning of gene expression through genetic rewiring with CRISPR-Cas9 …
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Deciphering the molecular components of the quorum sensing system in the fungus Ophiostoma piceae
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Extracting the Secrets of Secondary Metabolites
… CRAGE-CRISPR combo helps further demystify biosynthetic gene clusters.  The Science Microbial secondary metabolites, … for survival, may now be easier to characterize following a proof-of-concept study in which researchers paired CRISPR and … The work conducted by the US Department of Energy Joint Genome Institute, a DOE Office of Science …
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JGI User Executive Committee Expands
… have been elected to the User Executive Committee (UEC) of the U.S. Department of Energy Joint Genome Institute … feedback on pangenome tool development. Maurice is a fungal evolutionary ecologist with interests in understanding which … approved CSP New Investigator proposal to understand the genetic basis of fungal community assembly on dead wood …
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Boosting Small Molecule Production in Super “Soup”
… Yeast strains engineered for the biochemical conversion of glucose to value-added products are limited in chemical … ways to accelerate bio-design and identifying the best sets of enzymes that enable synthesis of sustainable … (BDO). To do so, the yeasts received fine-tuning of gene expression through genetic rewiring with CRISPR-Cas9 …
Learn more
JGI Scientists Pen Genome Watch Articles
… more to come in 2020. Researchers at the U.S. Department of Energy (DOE) Joint Genome Institute (JGI), a DOE Office … and metagenome , rather than just by 16S ribosomal RNA gene censuses.  Emiley Eloe-Fadrosh ,  Metagenome Program … Igor Grigoriev took readers on a quick romp through the  evolution and domestication of yeast , a model eukaryote. …
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Nigel Mouncey
… Dr. Mouncey joined the DOE Joint Genome Institute in 2017 as the fourth Director in its 27-year history. He has a wealth of managerial experience from almost 20 years in the … Dr. Mouncey has a long-standing interest in microbial genetics that started with his education and carried forward …
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Jeremy Schmutz
… Mr. Schmutz’s involvement with the JGI dates back to 1997, when he was … human chromosomes 5, 16, and 19. Following the completion of the Human Genome Project in 2003, he developed … assembly, and improvement strategies for de novo sequencing of eukaryotic organisms from simple yeasts to large …
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Designer DNA: JGI Helps Users Blaze New Biosynthetic Pathways
… A special issue of Synthetic Biology celebrates research enabled by the JGI … Fashioning DNA outside a cell is key to interrogating what genes do, how they work, and applying them to environmental … more than 10 papers, including two Nature Plants publications, in five years, have come out of the …
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An Inside Look at How Plants and Mycorrhizal Fungi Cooperate
… A new view into a symbiosis could offer benefits to address climate … change: pulling atmospheric carbon into soil and boosting biofuel feedstocks with less fertilizer. For millions of … interaction up close, using RNA sequencing to understand gene expression: one of the first cross-kingdom …
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