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… tell a quick story. Looking back, the year was probably 2010, 2011, I was a, uh- actually, I’ve got the t-shirt on … episode, we talked about genome mining through some metagenome associated genomes. And yes, antiSMASH is … Yeah. There’s so much to do there especially looking at metagenomes. So we’re actually eager soon to also work on …

… on DNA sequencing and synthetic biology. But also the metagenomics and gut microbiome, as I think that it’s like a … So they’re in the picomolar range. ALISON: Picomole… is [10 to the] minus twelve, right? BEN: Yeah, yeah. Well, we … enediynes to the market in 2001 with a drug called Mylotag. Wyeth was later acquired by Pfizer in 2009. So, a …

… we want to talk a little bit about. It’s sort of early stages. But I think that is emblematic of some of the … convince those people of that fact, however, a long time, 10 years! ALISON TAKEMURA: Wow. It’s all happened so fast. I … of the molecules in ecology. And that took another 10 years at least. But I had several students. And I worked …

… and secondary metabolites information from isolate and metagenome data.   The SMC ( smc.jgi.doe.gov ) is designed … is already the most comprehensive BGC database available at 10X the scale of the closest comparable database, and has … Expansion of the SMC to include fungal, plant, viral, and metagenome data is currently underway. … U.S. Department of …

The Metagenome Program uses advanced sequencing technologies to … and characterizing microbial diversity, work in the Metagenome Program uses several experimental approaches to … advance our understanding of Earth’s ecosystems. … The Metagenome Program focuses on the high-throughput sequencing …

… happens to that storage when a rainforest hits a drought. Tag along with their experiments in a fully enclosed, …

And I set that up. And we finally got that to work 10 years later. But in the meantime there, we had people … a teaspoon of soil from outside, you maybe have to do a 10,000-fold dilution to plate that out. The deeper you go in … by chemical synthesis and make analogs in combination of mutagenesis and direct evolution. Yeah. DAN UDWARY: So it’s …

… vector of choice Glycerol stock of sequence verified clone 102/NA DNA Synthesis Constructs 5-10kb in size Single gene … metabolites and unidentified features in spectra. 167/214 Metagenome Metatranscriptome Environmental transcript sequence Assembly, annotation ( IMG/M ), mapping 273/273 Metagenome Cell Enrichments Obtained by physical separation of …