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A Better Way to Find RNA Virus Needles in the Proverbial Database Haystacks
… Team develops a computational pipeline to sift and … (Berkeley Lab) describe a computational pipeline that can specifically scan for those snowflakes, or RNA virus … in the snowstorm of genomic data involved developing special computational sieves to filter out sequences that …
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An Enzyme Family that Helped Shape Nitrogen Metabolism on Our Planet
… Researchers looked across many organisms to see that … of Sciences bridges this gap, by tracing the evolution of a specific enzyme family called aminotransferases (ATs). These … to look at how this enzyme family evolved across 90 species. “One unique thing about this work was our focus on …
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Charting Progress toward Professional Goals
… Select interns look back on meaningful lessons from their summer experiences at … the JGI Berkeley Lab offers a variety of programs to help inspire and train the next generation of STEM professionals. … before so, getting to have this experience was very novel for me, and especially in like a biological field. …
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An Age of CRAGE: Advances in Rapidly Engineering Non-model Bacteria
… A group led by JGI scientists have made strides in improving … used CRAGE to engineer domesticated bacterial strains with novel biosynthetic gene clusters (BGCs). BGCs make diverse … Pseudomonas  and Ralstonia with enzymes that make phosphate bioavailable for plants. When these engineered …
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FICUS Webinar: “Shining a Light: Advanced Photon Source Capabilities for FICUS Research”
… On February 8, 2024, the DOE Joint Genome Institute and the Environmental Molecular Sciences Laboratory hosted a webinar to … Q(uestion) 1: Can researchers perform suggested treatments in the NEON … : For general questions, contact  Karolina Michalska . For specific questions about APS capabilities, contact  Zou …
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Building Wet and Dry Lab Skills
… Summer 2025 marked the second year of Alabama A&M University students … the plant microbiome. This year, however, there was a new aspect to the project - they also worked with Sharon … data via programming languages like Python. The more specific goal of the project is to determine how mutations …
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A Revamped Amplification Method that Enables Nearly Complete Single-Cell Genomes
… With a new methodology, scientists are now getting more complete … for understanding the microbiome of the earth, but most species do not grow easily in the lab. To access the genomes … of collecting them is through a method called Multiple Displacement Amplification, and most genomes that were …
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Learning to Look
… Machine learning approach significantly expands inovirus … of distinguishing features. Several characters may be spotted with a striped scarf, striped hat, round-rimmed … The U.S. Department of Energy Joint Genome Institute, a DOE Office of Science User Facility  located at Lawrence …
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Extracting the Secrets of Secondary Metabolites
… CRAGE-CRISPR combo helps further demystify biosynthetic gene clusters.  The Science Microbial secondary metabolites, those molecules not essential for … a proof-of-concept study in which researchers paired CRISPR and CRAGE technologies. While CRISPR (Clustered …
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JGI@25: Building a Better Bean
… In honor of the JGI's 25th anniversary in 2022, we have revisited a number of notable … of the bean. Though the JGI no longer works on food crops specifically, “[At the JGI] we do use Phaseolus as a test … manipulate. One important improvement to the bean spawned from this original research is the “slow-darkening” …
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Mining Metagenomes for Cas Proteins
… Cas14 proteins discovered from JGI’s IMG/M database and biochemically characterized at UC Berkeley and the Innovative Genomics Institute.  The Science Researchers report the discovery of miniature Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) associated …
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An Earth Month Look at Sustainability Efforts at the JGI
… Sustainable Berkeley Lab maintains a  calendar of Earth Month … everyday activities, striving for sustainability in lab spaces as well as offices. These efforts dovetail into … of materials used — from their creation to their disposal.  To minimize emissions from the disposal end of that …
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