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The INSIG2 rs7566605 genetic variant does not play a major role in obesity in a sample of 24,722 individuals from four cohorts
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JGI Launches Latest Strategic Plan
… For the Joint Genome Institute, the end of 2018 was marked by a … JGI supports, include JGI’s emerging leadership role in a Microbiome Data Science effort (pages 37-39) and the …
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An Age of CRAGE: Advances in Rapidly Engineering Non-model Bacteria
… ( CRAGE ). CRAGE enables scientists to insert large pieces of DNA (up to 60 kb) in a single step, directly into the … domesticate some 60 strains, inserting into them a genetic sequence that acts as a “landing pad.” Mouncey adds, … have also harnessed CRAGE to create a plant-fertilizing microbiome. In work  reported in  Applied and Environmental …
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DAP-seq Drives Robust Mapping of Gene Regulation
… Multi-species assays yield an unprecedented view of plant evolution and adaptation.    Understanding how genes are regulated is like deciphering the complex … where transcription factors (TFs) — the proteins that flip genetic switches — bind DNA were limited to a few model …
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A Community Resource for Secondary Metabolite Researchers
… user engagement. The Science In addition to the core set of "primary metabolites"—chemical compounds shared by most … Metabolism Collaboratory (SMC) has launched as an interactive public database for the research community. With more than 13 million BGCs in the catalog at the time of publication, it is the largest repository of BGC sequence …
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A new reference genome for Sorghum bicolor reveals high levels of sequence similarity between sweet and grain genotypes: implications for the genetics of sugar metabolism
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Genetic Analysis of Physcomitrella patens Identifies ABSCISIC ACID NON-RESPONSIVE, a Regulator of ABA Responses Unique to Basal Land Plants and Required for Desiccation Tolerance
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Ancient Algae Reveal Secrets of Plant Evolution
… Research uncovers the genetic foundations that helped plants conquer land over 600 million years ago. The Science By studying the genes of land plants’ closest algal relative,  Zygnematophyceae , … Settlement Biomedical Research Enhancement Funds as part of a startup grant of the University of Nebraska Lincoln, …
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Bacteria and Fungi Divvy Up the Work in Forest Floor
… second fiddle to those from fungi when it comes to breaking down tough plant fibers. The Science Walk in a temperate … analyzing the enzymes present in the complex organic matrix of the forest floor, a team of researchers have found that … of labor between the two groups. Fungi are much more active in degrading plant matter, and bacteria are more …
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Understanding Wildfire Recovery, Starting in Soil
… a wildfire. The Science After a wildfire burns, recovery begins at the forest floor. Within the soil, a microbiome of bacteria, viruses and fungi process carbon and nitrogen, … Sciences Laboratory (proposal ID 49615), which is a DOE Office of Science User Facility. This facility is sponsored …
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Effects of Polar Light Cycle on Microbial Food Web
… Populations of Antarctic lake microbial communities change with the seasons. The Science Light-harvesting bacteria (phototrophs) in Antarctica’s Ace Lake defy the … for metagenomic sequencing. A study  recently published in  Microbiome shows that the way nutrients flow through the …
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GenomeOcean Leverages AI to Decode Nature’s Secret Language
… genome discoveries. Unlocking the intricate details of life’s genetic blueprint has long been a significant challenge in … ecological Harvard Forest project, large datasets from soil microbiome studies collected across various terrains, and … The U.S. Department of Energy Joint Genome Institute, a DOE Office of Science …
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