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Welcome back to Natural Prodcast. This continues the series of interviews we recorded at the Society for Industrial … enzymes are, right? ALISON NARAYAN: Yes, and so that’s why I don’t like that sentence. I think that sometimes, we … association that might help? Like, if you have an unknown sequence or new flavin monooxygenases, you could say, oh …

… culture-disconnected. Like we’ll take some soil samples and sequence all the bugs out of that or whatever. And so I was … able to not only purchase their own HPLC to enable faster analysis of their plant extracts, but also establish their … methicillin-resistant Staphylococcus aureus . Can you share why finding treatments for these microbes is so important? …

JGI Mission As a U.S. Department of Energy Office of Science user facility supported by the … DNA design and synthesis, metabolomics and computational analysis that enable systems-based scientific approaches to … in doing so enabled the JGI to be the first to publish the sequence analysis of the target chromosomes 5, 16, and 19, …

… … DAN: Hey, everybody. Welcome back for another episode of Natural Prodcast. Right now I’m working on this the … of their synthases so that we can start to use the DNA sequence to predict or just understand better the language … your interest in getting into natural products. DAN: Why are you here at SIMB? AARON PURI: Yeah. Thanks Jackie. …

… … DAN: You’re listening to the US. .Department of Energy Joint Genome Institute’s “Natural Prodcast,” a … at genomes and seeing where the really hard things to sequence were, and wondering what those … what those were … functional was these secondary metabolite pathways. So why was that? What is it about secondary metabolite pathways …

See below for examples of successful Letters of Intent to our Community Science Program Large-Scale Call, … drafted them.  … Elucidating Sphagnum microbiome genetic interactions for improved growth at elevated temperatures … …

… … DAN: You’re listening to the US Department of Energy Joint Genome Institute’s “Natural Prodcast,” a … DAN: Alright, so I think we’ve covered a little bit about why they’re important. But one of the things I did want to … live in the root nodules of plants. And these guys were sequenced, and you can see that different Frankia have …

… — before any work can begin, including the submission of samples for sequencing, or the submission of sequencing data for synthesis. This agreement, required … Agreement and Appendix. An Appendix identifies the type of work or specific proposal to be covered under the …

… on genomic science projects that address sustainable biofuel and bioproducts production, leveraging systems-based approaches to unravel functional capabilities of plants, microbes and microbial communities, global carbon … accepted proposals, sequencing, synthesis, metabolomics and analysis will be paid for by the Department of Energy’s …

And at the time, it was really exciting when people would sequence [DNA]. The genome was– well, that hadn’t really … polyketide synthase and then P3. We still don’t know why 20 years later. JACKIE WINTER: It’s pretty amazing, … of what’s out there so that we can do more comparative analysis and maybe– I don’t know– start to put some of these …

… synthesis, and metabolomics at the JGI for projects of relevance to Department of Energy (DOE)  Mission Areas . … accepted proposals, sequencing, synthesis, metabolomics and analysis will be performed by the JGI at no cost to the … large. In most cases where the JGI provides more customized analysis, the JGI also participates in publication of …

… (Trillions) Operating Hours Goal Actual Total* Actual % of Goal Goal (hours)** Actual Total Actual % Goal FY 2025 … = 91 days; Actual Operation = 24 days due to significant sequencer downtime related to the shelter-in-place. ††† … 8734 2005 28 33.63 8400 8760 * Reflects actual data due to analysis beyond fiscal year-end close. …