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An Age of CRAGE: Advances in Rapidly Engineering Non-model Bacteria
… is central to our ability to offer host-engineering for our users,” says JGI Director Nigel Mouncey. Using CRAGE, JGI has established a portfolio of microbial hosts that users can select to be engineered. “Piloting access to this …
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Learning to Look
… Machine learning approach significantly expands inovirus diversity. To answer the question, “Where’s Waldo?” … (DOE) Joint Genome Institute (JGI), a DOE Office of Science User Facility, developed an algorithm that a computer could use to conduct a similar type of search in microbial and …
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JGI@25 RECAP: 2022 Annual Meeting features historical perspectives on JGI’s 25 years
… all that it has contributed, and what they’re excited about in JGI’s future. Find recordings and recaps of these … to be junk DNA, so there was quite a bit of resistance to use resources to sequence it,” Patrinos said. After many … of a genomic arms race as they recognized the private industry’s interest in simultaneously sequencing the human …
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Yasuo Yoshikuni
… Biology Pathway Engineering group. His research focus includes engineering of non-model yeasts for production … microbe-microbe and plant-microbe interactions in various environments to improve crop yield, and developing a … startup, Bio Architecture Lab, Inc. (BAL), where he used systems and synthetic biology to discover novel …
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DAS Tool for Genome Reconstruction from Metagenomes
… The work aligns with the ETOP mission of providing JGI users with the most current technology and expertise in … and soil from the Angelo Coast Range Reserve in California. Using DAS Tool on data from soil samples, researchers were … genomes with >90% completeness. These results, noted JGI User Programs Deputy Susannah Tringe , suggest that …
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The fungus that made itself at home
… the dry rot ( Serpula lacrymans ) is so destructive in houses. A study involving six brown rot fungi reveals the … towards breaking down plant mass for conversion to sustainable, alternative biofuels and bioproducts. This study lends insights on how the fungus has responded to manmade changes in its ecological …
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Innovative Technology Improves Our Understanding of Bacterial Cell Signaling
… bacterial interactions with animals and plants, or cause metal corrosion in oil pipes. Scientists have tried to … require external illumination, making them difficult to use inside deep tissues. Additionally, all plants, many … need external illumination to produce a signal, making them useful in a wider range of environments. This new technology …
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Iron-rich Microbial Mats’ Main Players: Marsarchaeota
… (thermophilic) microbes are of interest for their potential use in number of biotechnological applications. Molecular … technology that enables researchers to generating thousands to millions of copies of a particular DNA sequence from just a few pieces of DNA. Summary The extreme environments …
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Defining a Pan-Genome for Antarctic Archaea
… sequences from six hypersaline lakes, researchers focused on understanding the genomic variation in haloarchaea … and possibly cold-temperature enzymes for biotechnological use. Summary Conditions such as extreme cold, high levels of … the DOE Joint Genome Institute, a DOE Office of Science User Facility, microbial ecologist Rick Cavicchioli and his …
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Open Frameworks Training the Next Generation of Scientists
… participants. Over the past two years, Myco-Ed has been used in 15 individual classrooms across the country, … DOE Joint Genome Institute (JGI), a DOE Office of Science User Facility, and the DOE Systems Biology Knowledgebase … student research and skill development while curating reusable microbiome data. Undergraduate educators are …
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First Monoploid Reference Sequence of Sugarcane
… difficult to sequence and assemble, in turn limiting the use of modern, genomic breeding in these crops. For diploid species, sequencing programs generally focus on a genotype with two identical sets of chromosomes to … successfully assembled a first monoploid reference sequence using a targeted approach that focused on the gene rich part …
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JGI Early Career Researchers Featured in mSystems Special Issue
… method of traditional shotgun metagenomics. One approach uses fluorescence-activated cell sorting (FACS) to sort … a recent Nature Communications paper, uncovering giant virus sequences in soil for the first time. A second approach … reconstructing genomes directly from the environment and focuses on sequence reads to link mobile elements such as …
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