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JGI@25: Solving the Mystery of the Missing Oil
… In honor of the JGI's 25th anniversary in 2022, we have revisited a number of notable achievements that showcase our collaborations and … tracked the thousands of bacterial and archaeal species using a DNA-based array developed at Berkeley Lab. Over the …
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Promoting the Power of Viral Metagenomics
… An article summarizing the field of viral metagenomics, authored by JGI researchers Lee … , was  recently published in the journal  Annual Review of Biomedical Data Science . The following guest piece was … and discuss some of the current challenges faced by those using metagenomics to try to understand the far-reaching …
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GenomeOcean Leverages AI to Decode Nature’s Secret Language
… genome discoveries. Unlocking the intricate details of life’s genetic blueprint has long been a significant … analyze but also create DNA sequences mimicking an array of microbial life. By leveraging massive user-generated … LLMs aren’t just for understanding the human language and using it to communicate with machines. It has been applied …
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Supporting Global Research into Actinomycetes
… ActinoBase offers a public portal of insight into special groups of … are also abundant in soil and can be used as biocontrol agents and to promote plant growth. It is the … Streptomyces and many other related organisms, requires using more specialized tools, skills and protocols,” …
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Engagement Webinar: Harnessing JGI’s Metabolomics Capabilities
… (CSP) . This includes mass spectrometry-based measurements of primary and secondary metabolites from plants, microorganisms, and environmental samples using targeted and untargeted approaches. The webinar featured  Trent Northen and Ben Bowen of the  JGI Metabolomics Program , along with Jenny …
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Computationally Classifying Fungal Lifestyles
… genomes to classify gene families. The Science As a proof of concept, researchers developed an algorithm that “taught” … (From Haridas S et al.  Studies in Mycology , 2020.) Using whole genome data from newly sequenced genomes, they … The work conducted by the U.S. Department of Energy Joint Genome Institute, a DOE Office of Science …
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Nikos Kyrpides
… 2004 to lead the Genome Biology Program and the development of the comparative analysis platforms for microbial genomes … Joint Genome Institute, Dr. Kyrpides led the development of the genome analysis and Bioinformatics core at Integrated … his postdoctoral studies with Carl Woese at the University of Illinois at Urbana-Champaign and at Argonne National …
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iPHoP: A Matchmaker for Phages and their Hosts
… With metagenomic sequencing, researchers have found more of these viruses than ever before, in all kinds of ecosystems. However, matching these viral genetic … of virus-host interactions opens the possibility of using phages to engineer microbial communities. One day, …
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Gene Expression: From On-Off Switch to Dial
… to expression, scientists can now opt for various shades of grey. The ability to fine-tune the level of gene expression allowed researchers to identify … of essential genes in metabolic networks that were missed using traditional approaches. This novel form of …
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Polar Phytoplankton Need Zinc to Cope with the Cold
… Antarctic algae need their vitamins; zinc fuels some of their most important functions. Even in the chilly waters of Antarctica, tiny ocean-dwellers called phytoplankton play … across different ocean latitudes from pole to pole, using metatranscriptome and metagenome data from the JGI. …
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Evolution of a Fungal Gene Expression Regulator
… Describing the largest analysis to date of the modified DNA base 5mC variations in fungi. The … themselves can also be modified. The best-known example of a modified DNA base is a methylation of the base cytosine … of specific 5mC methyltransferase (MTase) variants. Using new sequencing technologies for producing both …
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Tracking the Origins of Methane-Producing Microbes
… archaea are estimated to produce 500 million tons of methane a year, which is over half the total global methane production. They are thought to use billions of tons of the carbon dioxide trapped in biomass each year … lab had previously collaborated with the JGI on a proposal using this approach through the Emerging Technologies …
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