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How Filamentous Fungi Sense Food
… Tracing gene regulatory networks in the model fungus  Neurospora crassa . The Science A team … used a multi-omics approach to reconstruct and model gene regulatory pathways used by the filamentous fungus  … We acknowledge the use of deletion strains generated by Grant P01 GM-068087 “Functional Analysis of a …
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GenomeOcean Leverages AI to Decode Nature’s Secret Language
… Trained on environmental data, a new JGI tool more accurately … discoveries. Unlocking the intricate details of life’s genetic blueprint has long been a significant challenge in genomics. Enter GenomeOcean, a powerful generative model  now available to the global research …
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Marine Microbe Contains Multitudes
… A deep dive into microbial genomics reveals one bacterial species is … to determine the genome structure of SAR324 cells and their gene expression, the team then sequenced community genomes and expressed gene transcripts (metagenomes, metatranscriptomes), as well …
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An Enzyme System to Help Catalyze Bioproduction of Plastic
… By characterizing the structure and function of a methylthio-alkane … an enzyme system that was previously only understood at a genetic level. Functional and structural experiments showed … convertible to ethylene, he began looking into the genetic foundations of what would become the MAR enzyme .  …
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The genome of Polaromonas naphthalenivorans strain CJ2, isolated from coal tar‐contaminated sediment, reveals physiological and metabolic versatility and evolution through extensive horizontal gene transfer
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From Intern to Published Scientist: The Journey of a JGI-UC Merced Intern
… For many scientists, the culmination of their work into a written report that is … a quest to better understand the factors and mechanics of gene expression in over 400 fungi species. “Fungi are the … “survival of the fittest” theory — the most expressed genes found across each of the fungal species were …
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Extracting the Secrets of Secondary Metabolites
… CRAGE-CRISPR combo helps further demystify biosynthetic gene clusters.  The Science Microbial secondary metabolites, … for survival, may now be easier to characterize following a proof-of-concept study in which researchers paired … is a technique researchers can use to integrate large genetic payloads directly into diverse microbes. Combining …
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Fungus Fuels Tree Growth
… Researchers start pinning down how a fungal symbiont spurs growth of poplar, a … studied what happens to the tree’s physical traits and gene expression when the fungus is present. The Impact Black … changes in plant roots),  M. elongata  doesn’t have as many gene products that directly influence plant phenotype, such …
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Engagement Webinar: Utilizing long-read sequencing for metagenomics and DNA modification detection
… This webinar focused on how the JGI employs single-molecule, … metagenomes are currently sequenced without pooling, which yields ~ 180 Gb of data per library. Q: How much … but we can already provide raw mapping files as well as gene- and contig-level coverage. Other related products Q:  …
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Whole metagenome sequencing and 16S rRNA gene amplicon analyses reveal the complex microbiome responsible for the success of enhanced in-situ reductive dechlorination (ERD) of a tetrachloroethene-contaminated Superfund site
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Tracking the Origins of Methane-Producing Microbes
… Mini-Metagenomics Approach Helps Identify Novel Archaeal … methanogenic archaea use one of three pathways for methanogenesis: hydrogen-dependent and CO2-reducing, or … and, acetoclastic. All three pathways require the gene cluster for methane production known as Mcr. Until …
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Ian Blaby
… Since 2019 Dr. Blaby heads the Biodesign Platform at the Joint Genome Institute, where he leads three groups focused on HTP DNA … view to developing a deeper understanding of sequence-based gene function. … B.Sc. (HONS) – University of Wales, Cardiff, Genetics Ph.D. – University of Cambridge., Microbial …
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