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… A team has optimized a crucial part of CRISPR-Cas9 technology to enable improvements in … their tool before felling their research problem: at a genetic level, how does  Y. lipolytica work? The project was … of researchers sought to disrupt every gene in the genome with CRISPR-Cas9 in order to interrogate each one’s …

… In honor of the JGI's 25th anniversary in 2022, we have revisited a … sequences have been cited in almost one-fourth (23.8%) of publications focused on that specific algae. The reference … lab and second author on the paper, studied viral genetics and gene therapy before self-training himself as a …

… survival, may now be easier to characterize following a proof-of-concept study in which researchers paired CRISPR and … is a technique researchers can use to integrate large genetic payloads directly into diverse microbes. Combining CRAGE with CRISPR provides researchers with a powerful addition to …

… The Science Anaerobic fungi, which die in the presence of oxygen, dwell in herbivore guts and help them digest … in their hunt for anaerobic fungi. By growing extracts without oxygen in ruminant fluid — which smells terrible … fungal natural products, O’Malley and her team plan to use genetic tools to boost production and isolate the compounds. …

… Miscanthus  sequence offers insights into benefits of polyploidy and … Department of Energy (DOE) Bioenergy Research Center, along with researchers from the Energy Biosciences Institute, the … numerous wild Miscanthus lineages to better understand the genetic diversity of the grass, which could help in …

… Maize produces a family of compounds that protects it against infections — using … Plants that the zealexin pathway has an “hourglass” shape with diverse precursors in, and many different products out, … They screened panels of hundreds of maize lines for genetic variation in the ability make zealexins, and …

… single-cell work — have quickly accelerated understanding of giant viruses. The Science In the last thirty years, in … , diversity exists in infectious cycles, as well, with viruses relying on different strategies for initiation, … methods, researchers have shed light on the genetic makeup of new giant viruses. This review highlights …

… than 20 UC Merced students have contributed to the research of 13 JGI scientists since the program’s inception. In 2014, … Zhong Wang and Science Programs Deputy Axel Visel teamed with University of California (UC), Merced assistant professor Suzanne Sindi …

… In April 2020, we mark both the 50th celebration of Earth Day on April 22, and DNA Day on April 25. As both … at the University of Hawai’i at Mānoa. I recently caught up with Karolina at the Plant and Animal Genomes, or PAG … they need. Karolina is working to better understand what genetic features make CAM possible. So, she’s studying …

… before. In 2006, the JGI produced 33 billion base pairs of sequence; by 2023, that number was almost 717 trillion. … such tools has been a collaborative effort. For example, with support from the  Exascale Computing Project , the JGI … are at the core of many environmental processes, and their genetic makeup forms the basis of their behavior in the …

… JGI interests in algae and secondary metabolites. A total of 27 proposals have been  approved through the annual  … users to explore data and share reproducible analyses with collaborators and the broader community. The approved … generating their  genome sequences to improve breeding by genetic improvements. Apomixis is asexual reproduction …

… at Lawrence Berkeley National Laboratory, and an Adjunct Professor of Plant and Microbial Biology at University of California, Berkeley. He contributed to the Human Genome … at the JGI. Click to learn more about the program's areas of focus, major initiatives and more.  …