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Udwary: You’re listening to the Department of Energy Joint Genome Institute’s Natural Prodcast, a podcast about natural … biological perspective, like what was this bacterium, and why did your group want to study it? Marnix Medema: You mean … sometimes correlated or anti correlated, also with other cellular functions in the same and as it was other bacteria …

… quantities of DNA derived from individual environmental cells. The proof of principle study built off earlier … year, the JGI team reported the first closed and finished genome derived from an uncultured bacterial single cell – a symbiont of the green sharpshooter. In 2012, …

… it so easily with fungi. So…   NANCY: Yeah, I don’t know why. For example, with that – actually there’s a good talk … parasite you really can’t grow well. You have to have it in cell culture. So we are going to see if we can express that … alone – I’m interested in pathogens. It’s just never a single microbe. And we have several recent papers and are …

… predict or just understand better the language of microbial cell-cell communication. And he told us about his work in … your interest in getting into natural products. DAN: Why are you here at SIMB? AARON PURI: Yeah. Thanks Jackie. … and they were able to synthesize the genes for every single one of those and put them in individual plasmids and …

… (BGCs), advancing pathway analysis, optimization of cell- and cell free-based expression platforms, tools and … We have developed Regulon Identification by in vitro-sequencing (RIViT-seq) to identify RNA polymerase-sigma … factors and determine their binding sites across multiple genomes. Computational prediction of heterologous …

… initiatives new to the JGI. Projects must be independent of ongoing JGI proposals, and lead PIs cannot have been lead … projects will provide pilot data to assess feasibility of a novel approach or form the foundation for a large-scale … an unlimited number of proposals).  For accepted proposals, sequencing, synthesis, metabolomics and analysis will be …

… be successful. Right? Because we don’t – drugs are usually single molecules, they are not extracts. And so yeah, in … Something that’s you know …  ALISON: Central! DAN: That’s why they called it that! But for, maybe, people who are less … in ourselves and every living thing that we know of with cells, and so… So you can think of DNA as maybe being …

… are complex organisms that harbor a fantastic diversity of cell types and associated organisms, including fungal and … genomics-powered tools to study this complexity, including single-cell and spatial transcriptomics barcode-based …

… constant developments to meet the ever-changing demands of our users. … Download plant, algal, fungal and microbial genomes and metagenomes — top-quality genomic data, open to … all JGI genomic databases and analytical tools for all JGI sequencing projects. In 2021, the JGI launched the Data …

For accepted proposals, sequencing, synthesis, metabolomics and analysis will be paid for by the Department of Energy’s funding of the JGI. There is no cost to the user … with DOE mission-relevant projects that call for expansive sequencing, synthetic biology and metabolomics capabilities …

… … DAN: You’re listening to the US Department of Energy Joint Genome Institute’s “Natural Prodcast,” a podcast about the … working with you, Dan, on this one, and we said, “Well, why don’t we have you know, the bioinformaticians go against … of, better understand fundamentally what’s going on in the cell as it responds to its ocean environment. And as we …