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… at genomes and seeing where the really hard things to sequence were, and wondering what those … what those were … functional was these secondary metabolite pathways. So why was that? What is it about secondary metabolite pathways … studied and in academia and industry can make many dozens of them. Some are going to be involved in antibiotic …

… readiness to begin work, checking such factors as genome size, polymorphism level, sample quality and availability, … … For sequencing projects, once work is under way, raw sequence data is released to NCBI’s Sequence Read Archive on a regular basis, in accordance with …

… are the RiPPs, which stands for “Ribosomally synthesized and Post-translationally modified Peptides.” You’ll have … you maybe explain what’s going on with their biology and why they’re so important to natural products? ERIC:  Sure. … turns a peptide, for example, from a disordered sequence into an antibiotic that kills bacteria through a …

… chemistry, and he has a project with the JGI to synthesize the genes for and explore the chemistry of quorum sensing … of their synthases so that we can start to use the DNA sequence to predict or just understand better the language … your interest in getting into natural products. DAN: Why are you here at SIMB? AARON PURI: Yeah. Thanks Jackie. …

Apple Podcasts or wherever you’re getting this and tell me why you’re listening. DAN: But, now, here’s Natural Prodcast … one more interview to do at SIMB. And sitting in the crazy hotel chair now is Roger Linington. Roger is a professor … And that’s been followed by developments in pulse sequences and improvements in the ways in which you acquire …

… happy today to be handing over our interview with Dr Elizabeth (or Betsy) Parkinson from Purdue University. She’s in … The genes are pretty much 100% identical. We don't know why one is expressed over the other. As far as whether we're … usually serve as dimers, and then they will bind to certain sequences of DNA. And when they bind to those certain …

… and bacteria, basically all living things. When your crazy Aunt is posting on Facebook about cinnamon or turmeric … stories about natural products, so you can get a feel for why I think they’re so important, and we’ll start to explain … more about some of the background and sort of the reasons why we want to do this. And also to provide a little more …

… of complex biological and environmental systems. We optimize our service to the community through responsibly managing … Berkeley Lab, leased laboratory and office space in a light industrial park in Walnut Creek, California, to consolidate … in doing so enabled the JGI to be the first to publish the sequence analysis of the target chromosomes 5, 16, and 19, …

… still almost certainly unusual things that we don’t recognize, because the only way to find things is by comparison. … DAN: Alright, so I think we’ve covered a little bit about why they’re important. But one of the things I did want to … live in the root nodules of plants. And these guys were sequenced, and you can see that different Frankia have …

… ecosystem. We are interested in how plants self-organize, influence, and are influenced by microbial partners. We … world. Research Team    … Plant microbiomes hold the amazing ability to influence plant development, fitness and … Resident viruses can be found in a myriad of bacterial strains, whereby they can modulate host metabolism, gene …

… sure we’ll hear more about that today. But it’s kind of amazing, just all of the things that Cassandra has done. And so … culture-disconnected. Like we’ll take some soil samples and sequence all the bugs out of that or whatever. And so I was … methicillin-resistant Staphylococcus aureus . Can you share why finding treatments for these microbes is so important? …