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… (see Auspice Statement below) for the generation of sequence or metabolomic data, DNA synthesized, and any other … annotation, comparative analysis, and interpretation of sequence, metabolomics, and functional genomics data types … for your proposal using your proposal's WIP ID (ex. 503582). Click on the correct proposal name on your search …

Duncan: Yeah. I love actinomycetes. Dan Udwary: Tell us why. I mean, I know, but I think– Alison Takemura: I want to … of almost finished characterizing them. We’ve got genome sequences, which are just incredible. We’ve looked at the … And we’ve given them genome sequences of some of these strains. They’re not all Pseudonocardia . There’s other very …

… at JGI start with sequencing, but where else did those sequences go? Like, what are the other scientific tools we … We don’t want to get a proposal that’s just asking for 20 microbial genomes. That is not a good fit for our annual … that describe the work. In general. Scientific merit and why it’s important. The DOE mission is one of these …

We focus our efforts on integrating database mining and sequence design with scaling the production of large, … developing methods for converting digital information from sequence databases into biotechnological or environmental …

… already had a fermentation process with already engineered strains, but this was to further build on those to try and … screening platform where we’d look at 10,000, 15,000, 20,000 mutants a week. We started doing a whole bunch of … to some people more about down the road. Email Nigel! He’ll sequence whatever you want!  [LAUGHTER]  NIGEL MOUNCEY: We …

… the global diversity of alternative genetic codes (Science 2014), unearthing hundreds of thousands of new viral genomes … analysis of thousands of archaeal and bacterial type strains ( GEBA-type strains project ), the delineation of … al. (2017) Protein structure determination using metagenome sequence data. Science   355(6322):294-298 Paez-Espino D. et …

… and eukaryotic microbes and viruses in environmental sequence data. We use multi-omics (metagenomics, … available at Google Scholar. Schulz, C Abergel, T Woyke (2022) Giant virus biology and diversity in the era of …

… through end-to-end automation, and further advancing sequence applications, single cell genomics, DNA synthesis, …

… tool BOOST , which provides a suite of tools to automate sequence design for assembly by Gibson, Yeast recombination …

… you maybe explain what’s going on with their biology and why they’re so important to natural products? ERIC:  Sure. … turns a peptide, for example, from a disordered sequence into an antibiotic that kills bacteria through a … tells you what some of those design rules might be and constrains hypotheses that you can test about how to put things …