Search

… Duncan: Yeah. I love actinomycetes. Dan Udwary: Tell us why. I mean, I know, but I think– Alison Takemura: I want to … of almost finished characterizing them. We’ve got genome sequences, which are just incredible. We’ve looked at the … And we’ve given them genome sequences of some of these strains. They’re not all Pseudonocardia . There’s other very …

… you maybe explain what’s going on with their biology and why they’re so important to natural products? ERIC:  Sure. … turns a peptide, for example, from a disordered sequence into an antibiotic that kills bacteria through a … tells you what some of those design rules might be and constrains hypotheses that you can test about how to put things …

… DAN: Alright, so I think we’ve covered a little bit about why they’re important. But one of the things I did want to … – how bacteria or other organisms communicate and how and why secondary metabolites are being produced in the … live in the root nodules of plants. And these guys were sequenced, and you can see that different Frankia have …

… out introns and dealing with, you know, weirdness in the sequence. You know, some clusters are not clustered…   … it so easily with fungi. So…   NANCY: Yeah, I don’t know why. For example, with that – actually there’s a good talk … this and that. They’re doing all this 16S and I said, “Why don’t you just include the ITS too? It’s so easy to add …

… then genomics happened. Dan: Yeah, I did my first genome sequence with you. Brad: That’s right,  Dan: JGI did it in … working with you, Dan, on this one, and we said, “Well, why don’t we have you know, the bioinformaticians go against … get made fun of by my now-wife, because she was wondering why it is that we needed to produce more toxins in the lab …

… Program aims to generate large datasets to explore sequence-function relationships, advancing the discovery of … Science Group supports researchers exploring how to convert sequence into functional assessments. The team has a … of fungi. Mycocosm enables users to navigate across sequenced fungal genomes, and to conduct comparative and …

… already had a fermentation process with already engineered strains, but this was to further build on those to try and … and so my team, we were responsible for coming up with new strains and new process improvements and new ways to recover … to some people more about down the road. Email Nigel! He’ll sequence whatever you want!  [LAUGHTER]  NIGEL MOUNCEY: We …

… at genomes and seeing where the really hard things to sequence were, and wondering what those … what those were … functional was these secondary metabolite pathways. So why was that? What is it about secondary metabolite pathways … favorite examples of a secondary metabolite producer, and why they produce those metabolites? MARC: Well, I’m really …

… analysis of thousands of archaeal and bacterial type strains ( GEBA-type strains project ), the delineation of host-virus … al. (2017) Protein structure determination using metagenome sequence data. Science   355(6322):294-298 Paez-Espino D. et … of Bacteria and Archaea: Sequencing a Myriad of Type Strains. PLoS Biology  12(8):e1001920 Ivanova N. et al. …