Search

… is like, what’s your origin story in natural products? Why are you doing this? JACLYN WINTER: I’ll kind of go back … JGI. These organisms we’re finding– at least by looking at their full genomes — are really not like anything that’s … have an E. coli strain that we’ve been working on that we sequenced the genome. And it has 17 resistant genes on a …

And at the time, it was really exciting when people would sequence [DNA]. The genome was– well, that hadn’t really … polyketide synthase and then P3. We still don’t know why 20 years later. JACKIE WINTER: It’s pretty amazing, … products. So after realizing that enzymes were specific for their substrates, that you couldn’t buy– there wasn’t a …

Duncan: Yeah. I love actinomycetes. Dan Udwary: Tell us why. I mean, I know, but I think– Alison Takemura: I want to … diversity, the sheer number of chemicals they produce, their ability to evolve, to go with horizontal gene transfer … of almost finished characterizing them. We’ve got genome sequences, which are just incredible. We’ve looked at the …

… product as we think about them in the natural products community, but it was again another product, an organism … of anything that’s relevant to the Department of Energy and their mission. And for a long time, I think, we’ve just been … to some people more about down the road. Email Nigel! He’ll sequence whatever you want!  [LAUGHTER]  NIGEL MOUNCEY: We …

…   Gain access to omics technologies generating community data at zero cost —  submit a proposal.  …

… capabilities support researchers exploring how to convert sequence into functional assessments. This is done by … design tool  … BOOST provides a suite of tools to automate sequence design for assembly by Gibson, Yeast recombination …

… able to explore DNA sequencing and actually get to the DNA sequence – sequences for the genes that code for the … Something that’s you know …  ALISON: Central! DAN: That’s why they called it that! But for, maybe, people who are less … When we grow things in the lab, we’re not growing them in their natural environment, we’re not subjecting them to the …

… below for examples of successful Letters of Intent to our Community Science Program Large-Scale Call, as well as …

I would say are are still fairly unexplored in terms of their natural products chemistry, and he has a project with … of their synthases so that we can start to use the DNA sequence to predict or just understand better the language … your interest in getting into natural products. DAN: Why are you here at SIMB? AARON PURI: Yeah. Thanks Jackie. …

… that maps gene expression patterns in the  Arabidopsis root, profiling nearly 100,000 single root cells and combining the information with previously … published in the journal  Developmental Cell and provides a community resource that could help researchers track cell …

… in the analysis and publication of the claimed genome sequences. This opportunity, provided by the Department of … builds upon thousands of microbial genomes that have been sequenced by the JGI though not formally analyzed or … necessary to extract meaningful biological insights from sequence data, employing IMG data and tools for comparative …