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… research, and also to talk to the wider natural products community about what they need to advance their science, and … stories about natural products, so you can get a feel for why I think they’re so important, and we’ll start to explain … right. So I did a PhD in microbiology at MIT, and I studied microbial ecology. I studied Vibrio species in the ocean, so …

… The Fungal & Algal Program explores the vast diversity of fungi and algae to unlock … The Fungal & Algal Program harnesses cutting-edge sequencing … Program aims to streamline genome analysis workflows for microbial eukaryotes, build fungal and algal pangenomes, and …

… then genomics happened. Dan: Yeah, I did my first genome sequence with you. Brad: That’s right,  Dan: JGI did it in … and Bill Fenical. And we connected to JGI through the Community Sequencing Program, and they worked with us to … working with you, Dan, on this one, and we said, “Well, why don’t we have you know, the bioinformaticians go against …

… of their synthases so that we can start to use the DNA sequence to predict or just understand better the language of microbial cell-cell communication. And he told us about his … your interest in getting into natural products. DAN: Why are you here at SIMB? AARON PURI: Yeah. Thanks Jackie. …

… Below is a brief description of the process needed to prepare and ship samples for sequencing by the JGI.  Additionally it … 1) Review JGI sample QC requirements and protocols Obtaining DNA and RNA of … QC Protocol DNA Extraction 101 : tips, kits, and protocols (from PacBio) Guidance for sample collection and storage …

… determine if these fungi act as friends or foes. The Impact Microbial communities comprised of fungi and bacteria can … Communications paper . The work was partly enabled by a JGI Community Science Program (CSP) proposal led by INRAE’s … from natural Arabidopsis populations around Europe. The JGI sequenced and annotated 41 fungal isolates from the …

… energy and infrastructure security. In complement to the Community Science Program, JGI researchers drive innovations … that cross the boundaries of the Plant, Fungal, Algal, Microbial, Metagenome, Metabolomics, Secondary Metabolites, and DNA Synthesis Science Programs and draw from the infrastructure of Genomic Technologies and Data …

… is a bacterial sacred metabolite, and ergot alkaloids come from fungi, and Taxol from plants. Plants, fungi, bacteria, … DAN: Alright, so I think we’ve covered a little bit about why they’re important. But one of the things I did want to … live in the root nodules of plants. And these guys were sequenced, and you can see that different Frankia have …

… would say that when I first started out the natural product community was almost 100% bacterial. Only people working in … out introns and dealing with, you know, weirdness in the sequence. You know, some clusters are not clustered…   … it so easily with fungi. So…   NANCY: Yeah, I don’t know why. For example, with that – actually there’s a good talk …

… And at the time, it was really exciting when people would sequence [DNA]. The genome was– well, that hadn’t really … polyketide synthase and then P3. We still don’t know why 20 years later. JACKIE WINTER: It’s pretty amazing, … of thought with that. So some people are interested in cave microbial– people are interested in the more extreme …

…   Gain access to omics technologies generating community data at zero cost —  submit a proposal.  … Our homepage video includes external footage from: University of …

… Apple Podcasts or wherever you’re getting this and tell me why you’re listening. DAN: But, now, here’s Natural Prodcast … to try and create an open source database of all known microbial natural products. So if you think about natural … And that’s been followed by developments in pulse sequences and improvements in the ways in which you acquire …