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… you maybe explain what’s going on with their biology and why they’re so important to natural products? ERIC:  Sure. … that’s making these compounds? So in the end, we took an approach that was kind of a simplified metagenome sequencing … turns a peptide, for example, from a disordered sequence into an antibiotic that kills bacteria through a …

… microbial communities using a variety of cutting-edge approaches.  Our group also seeks out new approaches that … offers the first quantitative Stable Isotope Probing (SIP) Metagenomics pipeline that utilizes internal analytical … access to cutting-edge cell sorting, DNA amplification, and sequence analysis to recover the genomes of uncultivated …

… then genomics happened. Dan: Yeah, I did my first genome sequence with you. Brad: That’s right,  Dan: JGI did it in … working with you, Dan, on this one, and we said, “Well, why don’t we have you know, the bioinformaticians go against … Patrick would spend time between our two laboratories doing metagenomics, some genomics. We were a little concerned …

… … DAN: You’re listening to the US Department of Energy Joint Genome Institute’s … DAN: Alright, so I think we’ve covered a little bit about why they’re important. But one of the things I did want to … live in the root nodules of plants. And these guys were sequenced, and you can see that different Frankia have …

Apple Podcasts or wherever you’re getting this and tell me why you’re listening. DAN: But, now, here’s Natural Prodcast … between those two groups and the ways in which they approached scientific problems. And so that sort of opened … And that’s been followed by developments in pulse sequences and improvements in the ways in which you acquire …

… 14 of Natural Prodcast . There’s been a lot going on, so I took a little break, but I’m hoping that from here I can get … functional genomics. And there’s a lot of sequencing based approaches, of course, now that we can use to figure that … to some people more about down the road. Email Nigel! He’ll sequence whatever you want!  [LAUGHTER]  NIGEL MOUNCEY: We …

… is like, what’s your origin story in natural products? Why are you doing this? JACLYN WINTER: I’ll kind of go back … have an E. coli strain that we’ve been working on that we sequenced the genome. And it has 17 resistant genes on a … And so we started thinking about if we had a different approach to this, how it should go. And so that’s where the …

… and DNA Day on April 25. As both Earth and DNA are close to our JGI hearts, we’re highlighting genomic science … Canal System,” focuses on anthropogenic impacts on wetland microbiome composition and metabolism, work on which … computational analysis that enable systems-based scientific approaches to these challenges.  DOE’s Office of Science is …

Platform capabilities support researchers exploring how to convert sequence into functional assessments. This is done by … design tool  … BOOST provides a suite of tools to automate sequence design for assembly by Gibson, Yeast recombination …

… … DAN: You’re listening to the US Department of Energy Joint Genome Institute’s … stories about natural products, so you can get a feel for why I think they’re so important, and we’ll start to explain … more about some of the background and sort of the reasons why we want to do this. And also to provide a little more …

… successful letters of intent and submissions at the bottom of the page.  … Review the list of open calls ; click on … for advice!      … The deliverables can range from raw sequence data to well-annotated assembled genomes to … listing of approved proposals can be found here. All sequence data will be accessible on the JGI Data Portal.   … …

… learned a lot so much history from this conversation about why the ocean was basically unexplored until the 70s, and … decided, what are these? And we did the ribosomal taxonomic approach, looking at that, which allows you to compare the … forward to seeing the data when it finally gets off the sequencers. The pandemic has obviously slowed JGI down a …