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… is like, what’s your origin story in natural products? Why are you doing this? JACLYN WINTER: I’ll kind of go back … on identifying and characterizing haloperoxidases from bacteria. And with Christian, I started getting a little bit … have an E. coli strain that we’ve been working on that we sequenced the genome. And it has 17 resistant genes on a …

… And at the time, it was really exciting when people would sequence [DNA]. The genome was– well, that hadn’t really … polyketide synthase and then P3. We still don’t know why 20 years later. JACKIE WINTER: It’s pretty amazing, … in the marine ecosystems and marine actinomycetes and cyanobacteria. And we thought we could also– let’s see what caves …

… culture-disconnected. Like we’ll take some soil samples and sequence all the bugs out of that or whatever. And so I was … a check-up on me. And I wonder how that intersects with bacterial bioprospecting that is often done, where we’re … methicillin-resistant Staphylococcus aureus . Can you share why finding treatments for these microbes is so important? …

… at JGI start with sequencing, but where else did those sequences go? Like, what are the other scientific tools we … that describe the work. In general. Scientific merit and why it’s important. The DOE mission is one of these … section. We want to be sure that the PIs can articulate why their work falls within one of these DOE mission areas. …

… capabilities and products . A minimum request of 1 Tb of sequence data is required to qualify for BERSS. For DNA … and personnel resources for genomic research and sequence-based science.  Projects include de novo generation …

… embargo starting at construct or strain delivery.  Detailed sequence information and constructs are made publicly …

… Our research focuses on the assembly of metagenomic sequence data into microbial genomes, which is of … between two genomes,  we use it to identify and classify bacteria and archaea as well as gain insights into the … Profile HMM search across all IMG metagenomes, capturing sequence diversity for proteins of interest. …

… capabilities support researchers exploring how to convert sequence into functional assessments. This is done by … BOOST provides a suite of tools to automate sequence design for assembly by Gibson, Yeast recombination …

… years, has been to bring generalizable technologies to bacteria, yeasts and algae previously with little to no …

… to some people more about down the road. Email Nigel! He’ll sequence whatever you want!  [LAUGHTER]  NIGEL MOUNCEY: We … An Age of CRAGE: Advances in Rapidly Engineering Non-model Bacteria Check out the agenda for the JGI’s 2021 Annual …

… our User Program’s Community Science Program, the JGI sequenced and characterized 270 genomes of the Clostridium … To meet these needs, the JGI deploys state-of-the-art sequencers and platforms dedicated to biodesign, single-cell …