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Every approved proposal starts with a User Agreement — before any work can begin, including … to the DOE, and publication requirements. An official with authority is usually an individual in a central office, … Officer/Director or Legal Representative. Please check with your unit director or supervisor for the appropriate …

… drug discovery train moving, drug companies started working with some techniques referred to as “combinatorial … as there were natural product hits. Sort of in parallel with that, the field of molecular biology got more … probably what you need to do is synthetic biology. That’s synthesizing the DNA that would be coding for that pathway …

… demands of our users. … Download plant, algal, fungal and microbial genomes and metagenomes — top-quality genomic … provides tools for analyzing the functional capability of microbial communities based on their metagenome sequence, in … over 15 million viral genomes and fragments, enriched with functional annotation, taxonomic classification, and …

… metabolism – field, though, is real, and it’s a field with very real and truly amazing science with a long … right. So I did a PhD in microbiology at MIT, and I studied microbial ecology. I studied Vibrio species in the ocean, so … We’re looking at a schematic of different pathways in a microbial cell, it looks like. It could be a eukaryotic …

… pathways. And today, we get to present our conversation with Marnix Medema , from Wageningen University in the … IMG kind of hooks into IMG’s data. IMG being Integrated Microbial Genomics at JGI, a large data set of bacterial … structural features to see if you can use that to predict activities, and the mechanisms of action, perhaps, even. I …

… of Delaware Laura.Selbmann©PNRA. All the sampling activities in Antarctica have been performed in the frame of … went on to advance basic science by sequencing scores of microbial species as well as several model organisms and … Integrative Genomics Building (IGB), a home it shares with the staff of the DOE Systems Biology Knowledgebase …

… including fungal and bacterial symbionts, detrimental microbial pathogens, and associated viruses that all … how plants self-organize, influence, and are influenced by microbial partners. We use a variety of genomics-powered … of their bacterial host to colonize plant roots, as with Arabidopsis thaliana. Using a coupled experimental and …

Metagenomic datasets could help map out microbial diversity hotspots Over the past few decades, … in sequencing technologies have led to an abundance of microbial genomes becoming available to the global research … Dongying Wu, a member of the Functional Annotation team within the JGI’s Microbiome Data Science group. “Turns out …

… 2 of our “primer” episode, so if you ended up here somehow without having listened to the first part, you might be a … conversation between myself and Alison, and we continue with the basic ideas of the science of natural products, and … metabolism pathways now, but there’s still almost certainly unusual things that we don’t recognize, because the only way …

… in making this happen. We had a really fun conversation with Roger about all this, in terms of how to build an … with institutions in Panama. And so I had this very unusual postdoc where I went to Panama, straight out of my … to try and create an open source database of all known microbial natural products. So if you think about natural …

… direct biochemical datasets to improve our understanding of microbial metabolism. Of particular interest is …