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… of secondary metabolism. Hey everybody, this is Dan with episode 13 of National Prodcast. This continues our … at the time and had some really tedious technical problems with editing the recording. But I recently changed the audio … and I hope you’ll enjoy it too. So here we go– episode 13 with Paco Barona-Goméz. DAN UDWARY: Hey Alison. ALISON …

… metabolism – field, though, is real, and it’s a field with very real and truly amazing science with a long … right. So I did a PhD in microbiology at MIT, and I studied microbial ecology. I studied Vibrio species in the ocean, so … We’re looking at a schematic of different pathways in a microbial cell, it looks like. It could be a eukaryotic …

… drug discovery train moving, drug companies started working with some techniques referred to as “combinatorial … as there were natural product hits. Sort of in parallel with that, the field of molecular biology got more … probably what you need to do is synthetic biology. That’s synthesizing the DNA that would be coding for that pathway …

… the public sector: academic and government institutions — with capabilities that had remained largely unknown and … Director Nigel Mouncey joined the JGI in 2017, he brought with him 20 years of industry experience — and an … will connect leading industry and academic organizations with the DOE, National Laboratories, and User Facilities — …

… Every approved proposal starts with a User Agreement — before any work can begin, including … to the DOE, and publication requirements. An official with authority is usually an individual in a central office, … Officer/Director or Legal Representative. Please check with your unit director or supervisor for the appropriate …

… kinds of biology, one of the best things that we do is work with this really great group of biologists that know what … tell us about this squid-microbe relationship. Or is it a microbial community with microbial community relationship?  … and it’s not 100% clear that we know what their biological activities might be. So our hypotheses around this have been …

… pathways. And today, we get to present our conversation with Marnix Medema , from Wageningen University in the … IMG kind of hooks into IMG’s data. IMG being Integrated Microbial Genomics at JGI, a large data set of bacterial … structural features to see if you can use that to predict activities, and the mechanisms of action, perhaps, even. I …

… 2 of our “primer” episode, so if you ended up here somehow without having listened to the first part, you might be a … conversation between myself and Alison, and we continue with the basic ideas of the science of natural products, and … metabolism pathways now, but there’s still almost certainly unusual things that we don’t recognize, because the only way …

… of Delaware; Laura.Selbmann©PNRA. All the sampling activities in Antarctica have been performed in the frame of …

… a new login service, requiring the use of an ORCID account with two-factor authentication enabled to log in. Check our … Download plant, algal, fungal and microbial genomes and metagenomes — top-quality genomic … provides tools for analyzing the functional capability of microbial communities based on their metagenome sequence, in …

… in making this happen. We had a really fun conversation with Roger about all this, in terms of how to build an … with institutions in Panama. And so I had this very unusual postdoc where I went to Panama, straight out of my … to try and create an open source database of all known microbial natural products. So if you think about natural …