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… focuses on the utility of single-cell methods to access genetic material of uncultivated taxa of interest. One such … V., Woyke T . Giant viruses with an expanded complement of translation system components.” Science 356(6333): 82-85 … … Research Interests … Former Lab Members … Selected Publications … For further details, please reach out to the …

I was imagining some massive contraption for amplifying genes. I wasn’t really sure what actinobacteria were. Dan … that. Dan Udwary: I want to point out, too, that your website is medicinesfromthesea.com, which is a great website … is a whole bunch of information that maybe never makes its publication. And these are little tips, you know, how to …

… along with their associated viruses and mobile genetic elements. Beyond exploring and characterizing … of viral, microbial, and microeukaryote genomes and mobile genetic elements, linked to custom interfaces and … We leverage  genome-resolved metagenomics and targeted gene searches to expand representation of uncultivated …

… declared the North Railroad Avenue Plume (NRAP) a Superfund site. The chemical PCE (perchloroethylene) found its way … it takes a (microbial) community to clean up a Superfund site. The Impact The Comprehensive Environmental Response, … (NCRR) (5P20RR016480-12) and the National Institute of General Medical Sciences (NIGMS) (8 P20 GM103451-12) from …

… for integrating data into IMG/M (see IMG/M submission site ). The Integrated Microbial Genomes (IMG) system serves …

… the catalytic cycle. So that co-factor stays in the active site. And then the other part of that, the monooxygenases, … could have arisen from. DAN UDWARY: OK, so sort of a phylogenetic reconstruction kind of a thing. ALISON NARAYAN: … they can just make the DNA and do in vitro transcription/translation to make their protein and run a reaction that …

… genomics existed. This is before we’re even thinking of genes and connecting genes to molecules, which is something that, you know, we … And so nature does that as well. But it does it with exquisite selectivity, exquisite control. And that’s a reaction …

… rights in technical data, project reporting to the DOE, and publication requirements. An official with authority is …

And we’ve done some work with those and have a couple of publications out there on the chemistry. There’s so much … coat is wrapping around, the bacteria are also being deposited in there. And so whether or not it’s the whole … products is that we don’t know what all the biosynthetic gene clusters look like.  DAN: For sure.  MARCY: We have so …

RiPPs, which stands for “Ribosomally synthesized and Post-translationally modified Peptides.” You’ll have to use your … see as the overall “theme” of your research? I know you’ve generally worked in various marine organisms. Except during … you’d like to read more about this, I highly recommend his publication last year, “The Biosynthetic Diversity of the …

… the most effective application, of marine molecules in general. DAN UDWARY: Maybe can you explain to our audience … that really looked promising. We found that there were new genera, these basic taxonomic group called the genus. We … Myers Squibb. And it is now in phase III in multiple sites, phase III human clinical trials. ALISON TAKEMURA: …