Search

… of it. So it wasn’t only chemistry or only biochemistry or genetics. It was also ecology. It was also evolution. It was … Usually, in a lot of cases, we still have to go through publications to get proteins, and their functions, and all … existing technology. And a lot of that was around chemical identification technology, mass spec, NMR. And we talked a …

… environment that influence system behavior.  Through this identification, metabolomics enables functional genome … products At JGI, in-depth molecular profiles are generated for metabolites extracted from a variety of …

… I was imagining some massive contraption for amplifying genes. I wasn’t really sure what actinobacteria were. Dan … that. Dan Udwary: I want to point out, too, that your website is medicinesfromthesea.com, which is a great website … is a whole bunch of information that maybe never makes its publication. And these are little tips, you know, how to …

… along with their associated viruses and mobile genetic elements. Beyond exploring and characterizing … of viral, microbial, and microeukaryote genomes and mobile genetic elements, linked to custom interfaces and … We leverage  genome-resolved metagenomics and targeted gene searches to expand representation of uncultivated …

… declared the North Railroad Avenue Plume (NRAP) a Superfund site. The chemical PCE (perchloroethylene) found its way … it takes a (microbial) community to clean up a Superfund site. The Impact The Comprehensive Environmental Response, … Act (CERCLA) was enacted by Congress in 1980 for Superfund sites which are hazardous waste areas that require cleanup …

… genomics existed. This is before we’re even thinking of genes and connecting genes to molecules, which is something that, you know, we … And so nature does that as well. But it does it with exquisite selectivity, exquisite control. And that’s a reaction …

… rights in technical data, project reporting to the DOE, and publication requirements. An official with authority is …

… the catalytic cycle. So that co-factor stays in the active site. And then the other part of that, the monooxygenases, … could have arisen from. DAN UDWARY: OK, so sort of a phylogenetic reconstruction kind of a thing. ALISON NARAYAN: … they can just make the DNA and do in vitro transcription/translation to make their protein and run a reaction that …

… And we’ve done some work with those and have a couple of publications out there on the chemistry. There’s so much … coat is wrapping around, the bacteria are also being deposited in there. And so whether or not it’s the whole … products is that we don’t know what all the biosynthetic gene clusters look like.  DAN: For sure.  MARCY: We have so …

… RiPPs, which stands for “Ribosomally synthesized and Post-translationally modified Peptides.” You’ll have to use your … see as the overall “theme” of your research? I know you’ve generally worked in various marine organisms. Except during … really need to know how they’re made. You need to bring the genes into the lab, and you need to manipulate them in the …