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… of Natural Prodcast. This week, Alison and I talk to Roger Linington, from Simon Fraser University in British Columbia, … if you standardize those, the MS-MS or MSn fragmentation patterns, in principle, the isotope patterns of those … to hear from you! We have projects in genome sequencing, DNA synthesis, transcriptomics, metabolomics, and natural …

… DAN: You’re listening to the US Department of Energy Joint Genome Institute’s … of, better understand fundamentally what’s going on in the cell as it responds to its ocean environment. And as we … a little bit more difficult. And so getting out clean DNA can also be a challenge there too. So JGI we really have …

… back to a new session of Natural Prodcast. I’ve got two things I wanted to tell you about in this introduction. First … which was a very early genome mining company, back when DNA sequencing of natural product pathways was hard and … come, though, too when you start talking about going after single gene clusters. BRIAN BACHMANN: That’s right. JACKIE …

… And we’ve done some work with those and have a couple of publications out there on the chemistry. There’s so much … local environments, and so they don’t transfer a lot of DNA back and forth, especially across species. And so then … synthase is very easy to search for because there are patterns of domains, protein domains that you look for. And …

… DAN UDWARY: You’re listening to the Department of Energy Joint Genome Institute’s … So you can start looking into these type of profiles or patterns from the molecular networking. So that’s one thing. … that people are using in the clinics were kind of kidnapped from nature without paying attention to the …

… In honor of the JGI's 25th anniversary in 2022, we have … high-quality genomic information using minute quantities of DNA derived from individual environmental cells. The proof … and finished genome derived from an uncultured bacterial single cell – a symbiont of the green sharpshooter. In 2012, …

… The JGI’s Microbial Program focuses on using cutting-edge sequencing, annotation and analysis techniques to explore the vast … The Microbial Program focuses on using advanced sequencing technologies to explore microbial … of bacteria and archaea in their natural environments using single cell approaches. This includes linking strain-level …

… Program works to uncover the roles of small molecules in biological systems, linking them with genomic data to enhance our understanding of … The Metabolomics Program is focused on understanding the critical roles of metabolites in living systems, particularly as they relate to DOE …

… Uncovering associations between plant roots and fungi that can help or harm plant host health. The … plants (endophytes). These include genes that degrade plant cell walls and break down plant sugars. The results also … The sequencing project was funded by the U.S. Department of Energy …

… for Episode 14 of Natural Prodcast . There’s been a lot going on, so I took a little break, but I’m hoping that from … our work in sequencing and genome mining with using DNA synthesis to express clusters metabolomics to be able to … help the Society grow. And so I’ve been the chair of the publications committee for the last, what is it now, five …

… Facility, the JGI serves more than 2,500 users that predominately come from the public sector: academic and government institutions — with capabilities that had remained largely … to test hypotheses via designed and assembled physical DNA constructs that can then be functionally characterized.  …