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… group aims at improving our collective understanding of ecological and evolutionary parameters driving virus:host … involves both experimental and computational exploration of uncultivated viral diversity, characterization of … mechanisms involved in virus:host interaction and host cell take-over by viruses, and attempts to evaluate …

… DAN: You’re listening to the US Department of Energy Joint Genome Institute’s “Natural Prodcast,” a … great conversations that we’ve already recorded with some excellent scientists, and that’s probably how we’ll continue … Craig Townsend at Johns Hopkins University. He does biosynthesis of natural product molecules and sort of the …

… know that that’s ever necessarily like a good description of anyone because chemistry means a lot, especially when … And we’ve done some work with those and have a couple of publications out there on the chemistry. There’s so much … genes in the organism in its sequence that encode for that biosynthesis. But sometimes you have to know what those are …

… The Fungal & Algal Program explores the vast diversity of fungi and algae to unlock their potential for bioenergy, … and bioproducts. By sequencing and analyzing the genomes of these organisms, the program investigates the biological … into practical applications, including sustainable biofuels, biomaterials, natural products, and environmental …

… — before any work can begin, including the submission of samples for sequencing, or the submission of sequencing data for synthesis. This agreement, required … rights in technical data, project reporting to the DOE, and publication requirements. An official with authority is …

… DAN: You’re listening to the US Department of Energy Joint Genome Institute’s “Natural Prodcast,” a … Eric for a long time – we worked together on Aflatoxin biosynthesis while he was a postdoc in Craig Townsend’s lab … way – the RiPP way, is to make a protein using the normal cellular way of making proteins, with a ribosome. Then, some …

… DAN: You’re listening to the US Department of Energy Joint Genome Institute’s “Natural Prodcast,” a … I did my Ph.D. with Craig Townsend and worked on aflatoxin biosynthesis, aflatoxin being a secondary metabolite from an … parasite you really can’t grow well. You have to have it in cell culture. So we are going to see if we can express that …

… Dan Udwary: You’re listening to the Department of Energy Joint Genome Institute’s Natural Prodcast, a … sometimes correlated or anti correlated, also with other cellular functions in the same and as it was other bacteria … at least parts of the structures of the molecules that use biosynthesis is encoded by these gene clusters and figuring …

… DAN: You’re listening to the US Department of Energy Joint Genome Institute’s “Natural Prodcast,” a … that – I want to say like lipid bilayer, you know, in the cell.  DAN: It depends on lifestyle. So there are lots of … drug discovery has been a major driver for natural product biosynthesis. And probably a lot of the people and the …

… The JGI’s DNA Synthesis Program supports a wide range of projects, from single-gene synthesis to the synthesis of entire chromosomes, advancing the development of biofuels, biochemicals and other bioenergy solutions.  … project. These advancements contribute to the development of new biofuels and sustainable biochemicals. The DNA …

… for you here today. We got the opportunity to talk to one of the real legends of natural products, Professor Bill … been described in such detail. DAN UDWARY: Alison, feel free to jump in with questions. But otherwise I’m going to … that the molecules out there would be toxic to cancer cells. And that started something big. Because at that time, …