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… seems hard to believe in retrospect. BILL FENICAL: Well, in 2021, absolutely hard to believe. But when you go way back, … do research. And it moved me to ask a simple question. In 1929, Alexander Fleming discovered a molecule called …

… and analytical tools for all JGI sequencing projects. In 2021, the JGI launched the Data Portal to eventually replace … serves as a community resource for comparative analysis and annotation of all publicly available genomes from three … integrated context. IMG/M provides tools for analyzing the functional capability of microbial communities based on …

… plant species. It was developed to improve plant genome annotations at the US Department of Energy (DOE) Joint … Atlas and PPRD could help with understanding gene functional roles, but the experimental inconsistency makes … at 18 different species, which included over 2000 RNA Seq libraries. As I previously mentioned, this is an updateable …

… to the second episode of the Natural Prodcast. This is part 2 of our “primer” episode, so if you ended up here somehow … is a time when all the big drug discovery companies were creating libraries of soil bacteria they kept and – ALISON: Yeah, …

… right? BEN: Yeah, yeah. Well, we are at [10 to the] minus 12 [Molar concentration]- is sufficient to kill cells. So … company Wyeth that introduced enediynes to the market in 2001 with a drug called Mylotag. Wyeth was later acquired by … six-membered aromatic ring. When they do that, they end up creating a “di-radical” which can wreak reactive havoc on …

Bacteria and Archaea has steadily been widening since 2005. This gap is also reflected in the strongly biased … of ‘homology creep’, function prediction as purely based on annotation may not be sufficient. A more recent effort in … cells are characterized and selected as based on a specific functional trait or phenotype of interest, prior to and in …

… this information freely to the public databases. In 2004, the JGI established itself as a national user … and has grown to serve a worldwide community of more than 2,000 primary users—those who apply for JGI resources and … constitute the largest reservoir of biodiversity and functional versatility on Earth. Their activities and …

… of cell-free based expression platforms: Only 10-20% of BGCs are expressed under standard laboratory … gene transfer. … The SMC provides complete sequence and annotation data for secondary metabolite biosynthetic gene … across all kingdoms of life. Tools are provided to display annotation data from many common software tools, and from …