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A team has optimized a crucial part of CRISPR-Cas9 technology to enable improvements in … genome with CRISPR-Cas9 in order to interrogate each one’s function. However, the team first needed to fix a defect in … lead Cas9 to make a lethal double-strand DNA break, a dysfunctional sgRNA would be harmless. The team was thus able …

As part of the ongoing partnership between DOE JGI and UC Merced to … Research Symposium , held February 6 at the University of California, Irvine, Cristhian and Bryan were among 5 UC … . Additionally, Bryan was featuring in a video about the importance of mentoring with Tanja Woyke and her research …

Twice a year, the DOE Office of Science Graduate Student Research (SCGSR) program … metabolism, work on which she will expand with her study of microbes in California’s manmade water transport canals. … of disciplines who seek to better understand the ecological importance of virus-microbe interactions,” Rambo added. Both …

… in their chosen field or fields through the publication of multiple highly cited papers during the last decade” by … the October issue of Nature, the study highlights the vast functional diversity of microbes by looking at protein function within them. …

… . The Science A team led by researchers at the University of California, Berkeley used a multi-omics approach to … N. crassa is the model organism for filamentous fungi, all of which contain a wide array of plant cell-wall degrading … use of deletion strains generated by Grant P01 GM-068087 “Functional Analysis of a Model Filamentous Fungus” and that …

… for a sustainable bioeconomy. Mission  As a U.S. Department of Energy Office of Science user facility, we provide … our work on four strategic themes: Nutrient Cycling, Functional Diversity, Data and Connectivity and Stewarding … enable our users to leverage biological and biochemical functions to meet climate and energy goals, improve food …

… (metagenomes). However, the quality and completeness of metagenome-assembled virus sequences vary widely. In a … that play key roles in cycling nutrients such as carbon, nitrogen and sulfur are themselves regulated by viruses in … limits the ability of researchers to accurately perform functional assessment, host prediction, and phylogenetic …

JGI-led team significantly expands the global diversity of large and giant viruses. While the microbes in a single drop of water could outnumber a small … Metabolic reprogramming, Schulz explained, makes the host function better under certain conditions, which then helps …

… from The Ohio State University and the University of Michigan studying how virus infections cause significant metabolic changes in marine microbes, the answer is no. They refer to the infected … is known about the impacts of these infections on ecosystem functions. As part of efforts to characterize global …

Large-scale comparative analysis leads to identification of biosynthetic gene clusters for novel secondary … small fraction of Earth’s microbial diversity. Because most microbes cannot be cultivated under laboratory conditions, … and it gives us new insights into microbial diversity and function.” He is already finding ways to utilize the catalog …

Genome Institute in 2016 and is leading the New Lineages of Life Group. His research is focussed on the discovery of novel bacterial, archaeal and eukaryotic microbes and viruses in environmental sequence data. Dr. … and phylogenomics) and machine learning to find novel functions that may impact microbiome structure and …

Miscanthus  sequence offers insights into benefits of polyploidy and perenniality. The Science A reference … life cycle. For example, in the fall the plants store nitrogen in its rhizomes – in the form of the nitrogen-rich …