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JGI@25: The Human Genome Project, or the JGI’s Origin Story
In honor of the JGI's 25th anniversary in 2022, we have revisited a number of notable achievements that showcase our collaborations and capabilities to enable great science that will help …
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For the Tiniest Archaea, A Genomic Switch of Friend or Foe
Meta-omics datasets show that CRISPR-Cas systems determine mutualism or parasitism between some archaeal hosts and … hitchhikers. These organisms are abundant and yet exceptionally small, with mini genomes to match. As a result, they … This shows that archaea may use CRISPR systems to protect against other, parasitic archaea. However, when  Ca . …
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An Age of CRAGE: Advances in Rapidly Engineering Non-model Bacteria
A group led by JGI scientists have made strides in improving and applying a method that allows researchers … team  announced in  Nature Microbiology an important addition to the synthetic biologist’s toolkit: a technique for  c … One , engineering different gene deletions in four gammaproteobacterial species, and then removing the editing …
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A Revamped Amplification Method that Enables Nearly Complete Single-Cell Genomes
With a new methodology, scientists are now getting more complete genomic results from single cells. The … DNA for genome sequencing was no easy task. The traditional way of collecting them is through a method called Multiple Displacement Amplification, and most genomes that were acquired through it were …
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Viruses Reprogram Cells into Different Virocells
Microbial cells infected by viruses undergo metabolic reprogramming. The … But if the duck gets infected by a virus so that it no longer looks or quacks like one, is it still a duck? For a … For this project, RNA sequencing was done by the JGI, and proteomics and metabolomics analysis and microscopy at EMSL. …
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Effects of Polar Light Cycle on Microbial Food Web
Populations of Antarctic lake microbial communities change with the seasons. The Science Light-harvesting bacteria (phototrophs) in Antarctica’s Ace Lake defy the …
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An Enzyme Family that Helped Shape Nitrogen Metabolism on Our Planet
Researchers looked across many organisms to see that aminotransferase enzymes have evolved mix-and-match … To boost crops more efficiently in the future, the evolutionary past may hold key insights. The way that plants … These enzymes are crucial for creating nucleic acids and proteins, as well as recycling nitrogen. Now, with insight …
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Mindfully Moving JGI
JGI is in the process of shifting its operations from Walnut Creek … the Berkeley Lab campus. By Friday, October 18, the production sequencing labs in Building 100 were silent. Twenty years …
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2024 Progress Report
The Integrative Genomics Building (IGB) seen above is home to … from the DOE Systems Biology Knowledgebase (KBase), the National Microbiome Data Collaborative (NMDC), and Berkeley Lab … sugarcane genome sequence. The JGI  partnered  with synchrotron user facilities to define the structure and function …
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Cultivating Symbiotic Antarctic Microbes
Nanohaloarchaeota cultures reveal they are symbionts and not free-living organisms. The Science Researchers employed multiple … in 2011, Nanohaloarchaea are part of the DPANN (Diapherotrites, Parvarchaeota, Aenigmarchaeota, Nanoarchaeota, and …
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Making a Lichen Together
… clearly. The Science The humble lichen is a superorganism: one being that is actually comprised of two (or more) participants. One is a fungus (usually belonging to the ascomycetes, one …
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Bacteria and Fungi Divvy Up the Work in Forest Floor
Bacterial enzymes play second fiddle to those from fungi when it comes to breaking down tough plant fibers. The Science Walk in a temperate … detailed database on the denizens in the soil. While large protein databases, like UniProt, exist, are not specific …
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