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A Revamped Amplification Method that Enables Nearly Complete Single-Cell Genomes
… scientists are now getting more complete genomic results from single cells. The Science Studying the  genomes of … years, extracting single cells and then amplifying their DNA for genome sequencing was no easy task. The traditional … together, they found most bacterial genomes from water and soil communities were at least 80% complete when studied …
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iPHoP: A Matchmaker for Phages and their Hosts
… opens the possibility of using phages to engineer microbial communities. One day, these phages could boost plant-microbe … reflecting factors such as the quality and number of datasets for human microbiome data. In other environments, such as terrestrial soil, having additional isolates and metagenomic datasets …
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Forming Scientific Connections and Building Community
… The 11th cohort of JGI-UC Merced interns pick highlights from their summer experiences. This year the U.S. Department … hosted three undergraduates and seven graduate students from UC Merced through their long standing internship … experience of living in another city, taking the shuttle from stop to stop and having responsibilities. I like the …
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From Intern to Published Scientist: The Journey of a JGI-UC Merced Intern
… into a written report that is published in a scientific journal is the ultimate achievement. To get to this point … covering the entire kingdom of fungi. “The information from this project may also have a practical relevance with … to learning about how to navigate and analyze large genomic datasets during the internship, Wint also began learning …
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Mapping the Earth’s Hidden Fungal Kingdom
… years, fungi have spread quietly throughout our planet. From the deepest ocean floors to Antarctic valleys, these … plant and animal genomes can sprawl across billions of DNA base pairs, most fungal genomes contain fewer than 50 … artificial intelligence to genomics. The comparative datasets that revealed evolutionary patterns are now …
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High-quality permanent draft genome sequence of Ensifer medicae strain WSM244, a microsymbiont isolated from Medicago polymorpha growing in alkaline soil
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Ian Blaby
… Institute, where he leads three groups focused on HTP DNA design and assembly, strain engineering and … Nature Communications 15(1) 3167. 2024 Simirenko et al ., gRNA-SeqRET: a universal tool for targeted and genome-scale … high-throughput platform at the Joint Genome Institute for DNA construct design and assembly—present and future …
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JGI@25: Expanding Metagenomics to Capture Viral Diversity
… host to replicate. Sequencing genetic material directly from samples sidesteps these challenges, since it doesn’t … In 2016, Nikos Kyrpides at the JGI led a team that combed datasets from around the world, finding over 125,000 partial … all over the world, including 3,908 isolate reference DNA viruses and 264,413 computationally identified viral …
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DOE Metrics
… capabilities to analyze complex genomic or metagenomic datasets. [Download PDF] Q3 – Report on new computational … computationally enabled approach to analyze complex genomic datasets. [Download PDF]   FY 2014 Overall Sequencing … Hours reflect a delay in implementation of the LIMS from Q2 to Q3. As a result of the delay in the LIMS …
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A Community Resource for Secondary Metabolite Researchers
… (BGCs.) As reported in the recent Database issue of the journal Nucleic Acids Research , the Secondary Metabolism … it is the largest repository of BGC sequence data from over 1.3 million publicly available bacterial and … gene clusters and secondary metabolites information from isolate and metagenome data.   The SMC ( …
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DAP-seq Drives Robust Mapping of Gene Regulation
… complexity of plant genomes. Now, with improvements to DNA Affinity Purification Sequencing (DAP-seq), these … evolutionary conservation; and integration with single-cell RNA sequencing reveals how transcription factors control … in plants such as  Arabidopsis and sorghum. Together, these datasets allow scientists to explore how gene regulation …
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Phototrophic Co-cultures From Extreme Environments: Community Structure and Potential Value for Fundamental and Applied Research
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