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DAP-seq Drives Robust Mapping of Gene Regulation
… Multi-species assays yield an unprecedented view of plant evolution and adaptation.    Understanding how genes are regulated is like deciphering the complex … The U.S. Department of Energy Joint Genome Institute, a DOE Office of Science User Facility located at Lawrence Berkeley National Laboratory, is committed to advancing genomics in …
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Tracking the Origins of Methane-Producing Microbes
… Mini-Metagenomics Approach Helps Identify Novel Archaeal Methane … Methane-producing archaea are estimated to produce 500 million tons of methane a year, which is over half the total … three pathways for methanogenesis: hydrogen-dependent and CO2-reducing, or hydrogenotrophic (most common); …
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A Complex Confection Decoded: Sugarcane Reference Genome
… Sugarcane was the last major crop without a reference quality … work toward advancing sugarcane biotechnology. The Science Considered the world’s most harvested crop by tonnage, … partly enabled by the JGI’s Community Science Program; in 2018, a monoploid reference sequence of sugarcane …
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Effects of Polar Light Cycle on Microbial Food Web
… Populations of Antarctic lake microbial communities change with the seasons. The Science Light-harvesting bacteria (phototrophs) in Antarctica’s Ace Lake defy the … This work was supported by the Australian Research Council (DP150100244) and the Australian Antarctic Science program (project …
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Better Genome Editing for Bioenergy
… A team has optimized a crucial part of CRISPR-Cas9 … technology to enable improvements in microbial oil production. The Science CRISPR-Cas9 is a powerful, high-throughput … CRISPR-Cas9 relies on RNA with a short guiding sequence (20 bp) that directs the endonuclease where to cut, but these …
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JGI@25: The Human Genome Project, or the JGI’s Origin Story
… In honor of the JGI's 25th anniversary in 2022, we have revisited a number of … with the HudsonAlpha Institute for Biotechnology.   Publications Grimwood, J., Gordon, L., Olsen, A. et al. The …
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JGI@25: Expanding Metagenomics to Capture Viral Diversity
… In honor of the JGI's 25th anniversary in 2022, we have …
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Innovative Technology Improves Our Understanding of Bacterial Cell Signaling
… Newly developed chemiluminescent biosensors shed light on how bacteria function and colonize diverse environments. The … 1) complementation of split luciferase (CSL) and, 2) bioluminescence resonance energy transfer (BRET)-based … The work conducted by the U.S. Department of Energy Joint Genome Institute is supported by the …
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Engagement Webinar: Harnessing JGI’s Metabolomics Capabilities
… The JGI Engagement Webinar held November 5, 2020 (watch the  video below, captions are available) spotlighted the metabolomic analysis … The U.S. Department of Energy Joint Genome Institute, a DOE Office of Science User Facility located at Lawrence Berkeley National Laboratory, is committed to advancing genomics in …
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Mapping the Earth’s Hidden Fungal Kingdom
… Leveraging massive comparative genomics to decode millions of … valleys, these organisms have diversified into an estimated 2–6 million species — dwarfing the diversity of plants. To … Earth's fungal kingdom. The manuscript reviews about 200 publications linking evolutionary history and innovations …
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Katherine Louie
… Dr. Louie joined the JGI in 2014 to develop the metabolomics program, and in 2019 became Platform Lead where she manages metabolomics production for community sequencing projects and heads R&D efforts … B.S in Biomedical Engineering, Johns Hopkins University; Ph.D. in …
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Mike Sneddon
… Dr. Sneddon is the Advanced Analysis Group Lead in the Data Science and Informatics Department at the Joint … genomics and lab informatics. Prior to joining JGI in late 2025, he served as Director of Scientific Computing at … Liu, O., Akiva, E., Eyles, T. H., Galm, U., Ganesh, S., Hendrix, S. …
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